INT213995

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank2) plasma membrane (Ank2) cytoskeleton (Ank2)
cytoplasm (Ank2)
Ank2 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 12 30.00 Quite Low
sodium channel 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 84 99.54 Very High Very High Very High
Kyphosis 8 98.84 Very High Very High Very High
Death 32 94.68 High High
Syncope 8 94.24 High High
Arrhythmia Under Development 88 93.88 High High
Alopecia 12 90.08 High High
Obesity 4 81.36 Quite High
Bradycardia 12 77.08 Quite High
Premature Aging 4 75.80 Quite High
Syndrome 32 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high degree of conservation across species suggests that these residues are likely to be critical for ankyrin-B stability and/or function.
Positive_regulation (critical) of ankyrin-B
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.08 Pain Relevance 0
mice could be that chronic elevation of [Ca2+]i transients in ankyrin-B+/?
Positive_regulation (elevation) of ankyrin-B
2) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.10 Pain Relevance 0
These data demonstrate that accelerated aging is a highly penetrant consequence of ankyrin-B-deficiency in mice.
Positive_regulation (consequence) of ankyrin-B associated with aging
3) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.61 Pain Relevance 0
mice display severe kyphosis which begins at 6 months of age and becomes increasingly pronounced in two year ankyrin-B+/?
Positive_regulation (pronounced) of ankyrin-B associated with kyphosis
4) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.07 Pain Relevance 0

General Comments

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