INT213995

Context Info Confidence 0.50 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.86 Pain Relevance 0

signal transduction (Ank2) plasma membrane (Ank2) cytoskeleton (Ank2) cytoplasm (Ank2)

Ank2 (Mus musculus)

Pain Link Frequency Relevance Heat Somatostatin 12 30.00 sodium channel 8 5.00 anesthesia 4 5.00 imagery 4 5.00 Catecholamine 4 5.00

Disease Link Frequency Relevance Heat Aging 84 99.54 Kyphosis 8 98.84 Death 32 94.68 Syncope 8 94.24 Arrhythmia Under Development 88 93.88 Alopecia 12 90.08 Obesity 4 81.36 Bradycardia 12 77.08 Premature Aging 4 75.80 Syndrome 32 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The high degree of conservation across species suggests that these residues are likely to be critical for ankyrin-B stability and/or function.

Positive_regulation (critical) of ankyrin-B

1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.08 Pain Relevance 0

mice could be that chronic elevation of [Ca2+]i transients in ankyrin-B+/?

Positive_regulation (elevation) of ankyrin-B

2) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.10 Pain Relevance 0

These data demonstrate that accelerated aging is a highly penetrant consequence of ankyrin-B-deficiency in mice.

Positive_regulation (consequence) of ankyrin-B associated with aging

3) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.61 Pain Relevance 0

mice display severe kyphosis which begins at 6 months of age and becomes increasingly pronounced in two year ankyrin-B+/?

Positive_regulation (pronounced) of ankyrin-B associated with kyphosis

4) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.07 Pain Relevance 0

General Comments

This test has worked.