INT213997

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.06
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank2) plasma membrane (Ank2) cytoskeleton (Ank2)
cytoplasm (Ank2)
Anatomy Link Frequency
skeletal muscle 7
pancreatic beta cells 3
lung 2
testes 1
brain 1
Ank2 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 11 73.52 Quite High
Somatostatin 33 59.92 Quite High
imagery 11 46.64 Quite Low
sodium channel 22 34.00 Quite Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 231 98.00 Very High Very High Very High
Disease 11 94.88 High High
Myocardial Infarction 77 94.36 High High
Neurological Disease 11 89.52 High High
Arrhythmia Under Development 242 89.20 High High
Diabetes Mellitus 11 87.12 High High
Sudden Death 33 77.68 Quite High
Syndrome 88 76.40 Quite High
Bradycardia 33 65.44 Quite High
Obesity 11 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high levels of ankyrin-B expression in the brain and pancreatic beta cells and early senescence in ankyrin-B+/?
Negative_regulation (levels) of Gene_expression (expression) of ankyrin-B in pancreatic beta cells associated with aging
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.90 Pain Relevance 0
We first compared effects of ouabain and ankyrin-B-deficiency on cellular shortening in freshly isolated unloaded wild-type and ankyrin-B+/?
Negative_regulation (deficiency) of Gene_expression (/) of ankyrin-B
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.12 Pain Relevance 0
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of Gene_expression (present) of Ankyrin-B in skeletal muscle
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
Untreated ankyrin-B+/?
Negative_regulation (Untreated) of Gene_expression (/) of ankyrin-B
4) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0 Pain Relevance 0
Abnormal calcium dynamics in ankyrin-B+/?
Negative_regulation (dynamics) of Gene_expression (/) of ankyrin-B
5) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.10 Pain Relevance 0.04
The high levels of ankyrin-B expression in the brain and pancreatic beta cells and early senescence in ankyrin-B+/?
Negative_regulation (levels) of in brain Gene_expression (expression) of ankyrin-B in pancreatic beta cells associated with aging
6) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.90 Pain Relevance 0
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of in lung Gene_expression (present) of Ankyrin-B in skeletal muscle
7) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of in kidney Gene_expression (present) of Ankyrin-B in skeletal muscle
8) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of in testes Gene_expression (present) of Ankyrin-B in skeletal muscle
9) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of in spleen Gene_expression (present) of Ankyrin-B in skeletal muscle
10) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Negative_regulation (levels) of in lung Gene_expression (present) of Ankyrin-B in skeletal muscle
11) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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