INT214

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Context Info
Confidence 0.81
First Reported 1970
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 370
Total Number 371
Disease Relevance 208.51
Pain Relevance 91.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 22
blood 16
urine 13
hypothalamus 8
pituitary 6
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 497 100.00 Very High Very High Very High
Catecholamine 244 100.00 Very High Very High Very High
alcohol 80 100.00 Very High Very High Very High
Endogenous opioid 70 100.00 Very High Very High Very High
Somatostatin 43 100.00 Very High Very High Very High
Dismenorea 38 100.00 Very High Very High Very High
Pain management 4 99.96 Very High Very High Very High
narcan 227 99.92 Very High Very High Very High
Opioid 93 99.92 Very High Very High Very High
Morphine 62 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyponatremia 1949 100.00 Very High Very High Very High
Stress 420 100.00 Very High Very High Very High
Natriuresis 154 100.00 Very High Very High Very High
Dysmenorrhea 27 100.00 Very High Very High Very High
Myocardial Infarction 480 99.96 Very High Very High Very High
Anxiety Disorder 105 99.96 Very High Very High Very High
Volume Depletion And Dehydration 78 99.96 Very High Very High Very High
Pressure Volume 2 Under Development 387 99.92 Very High Very High Very High
Abdominal Pain 39 99.92 Very High Very High Very High
Convulsion 60 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone decreases the inhibitory effect of ethanol on the release of arginine-vasopressin induced by physical exercise in man.
Localization (release) of arginine-vasopressin associated with narcan
1) Confidence 0.81 Published 2009 Journal J Neural Transm Section Title Doc Link 19649691 Disease Relevance 0 Pain Relevance 0.42
When ethanol tests were repeated in the presence of naloxone, at both lower and higher dose, ethanol inhibition on AVP secretion was only partial, with mean peak responses 2.5 times higher than basal values.
Localization (secretion) of AVP associated with narcan
2) Confidence 0.81 Published 2009 Journal J Neural Transm Section Abstract Doc Link 19649691 Disease Relevance 0 Pain Relevance 0.40
In order to establish whether ethanol exerts its inhibiting effect on the nicotine-induced release of arginine-vasopressin (AVP) by interacting with an opioid pathway, six normal volunteers were treated with naloxone (2 or 4 mg as IV bolus, plus 5 or 10 mg infused over 105 minutes) during (2 nonfilter) cigarette smoking and ethanol (50 mL to 110 mL of whiskey) drinking.
Localization (release) of arginine-vasopressin associated with nicotine addiction, nicotine, narcan and opioid
3) Confidence 0.81 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3600293 Disease Relevance 0.24 Pain Relevance 0.42
In order to establish whether ethanol exerts its inhibiting effect on the nicotine-induced release of arginine-vasopressin (AVP) by interacting with an opioid pathway, six normal volunteers were treated with naloxone (2 or 4 mg as IV bolus, plus 5 or 10 mg infused over 105 minutes) during (2 nonfilter) cigarette smoking and ethanol (50 mL to 110 mL of whiskey) drinking.
Localization (release) of AVP associated with nicotine addiction, nicotine, narcan and opioid
4) Confidence 0.81 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3600293 Disease Relevance 0.24 Pain Relevance 0.42
When given alone, naloxone and ethanol did not modify AVP secretion, whereas nicotine increased plasma AVP levels by about 2.5-fold.
Localization (secretion) of AVP in plasma associated with nicotine and narcan
5) Confidence 0.81 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3600293 Disease Relevance 0.26 Pain Relevance 0.69
In normal man, the centrally active alpha2-adrenoceptor agonist clonidine reduces arginine-vasopressin (AVP) secretion, probably by presynaptic inhibition of noradrenergic neuron terminals in the supraoptic nucleus.
Localization (secretion) of AVP in supraoptic nucleus associated with agonist and clonidine
6) Confidence 0.81 Published 1999 Journal Clin. Auton. Res. Section Abstract Doc Link 10580879 Disease Relevance 0.43 Pain Relevance 0.50
In normal man, the centrally active alpha2-adrenoceptor agonist clonidine reduces arginine-vasopressin (AVP) secretion, probably by presynaptic inhibition of noradrenergic neuron terminals in the supraoptic nucleus.
Localization (secretion) of arginine-vasopressin in supraoptic nucleus associated with agonist and clonidine
7) Confidence 0.81 Published 1999 Journal Clin. Auton. Res. Section Abstract Doc Link 10580879 Disease Relevance 0.43 Pain Relevance 0.50
Effect of naloxone on the inhibitory effect of melatonin on the release of arginine-vasopressin induced by physical exercise in man.
Localization (release) of arginine-vasopressin associated with narcan
8) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Title Doc Link 20346989 Disease Relevance 0 Pain Relevance 0.40
The effect of the cold pressor test on vasopressin secretion in man.
Localization (secretion) of vasopressin associated with pain
9) Confidence 0.81 Published 1986 Journal Psychoneuroendocrinology Section Title Doc Link 3786636 Disease Relevance 0.18 Pain Relevance 0.18
Stress has been thought to induce the release of arginine vasopressin (AVP).
Localization (release) of AVP associated with stress
10) Confidence 0.81 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3786636 Disease Relevance 0.17 Pain Relevance 0.07
We evaluated this claim by studying the effects of a modified cold pressor test on plasma AVP, plasma cortisol, blood pressure, pulse rate, and a number of variables known to affect AVP secretion.
Localization (secretion) of AVP in blood
11) Confidence 0.81 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3786636 Disease Relevance 0.18 Pain Relevance 0.09
Noradrenaline (norepinephrine) has a complex effect on vasopressin secretion [49].
Localization (secretion) of vasopressin associated with noradrenaline
12) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.67 Pain Relevance 0.48
Of the total stock of vasopressin, 10–20% can be rapidly released into the bloodstream [8].
Localization (released) of vasopressin
13) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.26 Pain Relevance 0
Vasopressin is secreted when arterial pressure falls to the point that it can no longer be compensated for by the predominant action of the vascular baroreceptors [45-48].


Localization (secreted) of Vasopressin
14) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.73 Pain Relevance 0.29
Other stimuli can favour secretion of vasopressin.
Localization (secretion) of vasopressin
15) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.69 Pain Relevance 0.36
The osmotic threshold for vasopressin secretion corresponds to a mean extracellular osmolality of 280 mOsmol/kg H2O (Fig. 2).
Localization (secretion) of vasopressin
16) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.41 Pain Relevance 0
Vasopressin secretion
Localization (secretion) of Vasopressin
17) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.18 Pain Relevance 0
The central osmoreceptors that regulate vasopressin secretion are located near to the supraoptic nucleus in the anterolateral hypothalamus in a region with no blood–brain barrier [20].
Localization (secretion) of vasopressin in blood
18) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.18 Pain Relevance 0
Arterial hypotension is the principal stimulus for vasopressin secretion via arterial baroreceptors located in the aortic arch and the carotid sinus (Fig. 2) [6].
Localization (secretion) of vasopressin in sinus associated with pressure volume 2 under development
19) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.48 Pain Relevance 0
Subsequently, vasopressin secretion that is paradoxically insufficient with respect to the level of hypovolaemia has been observed [3,10,12,14,19].
Localization (secretion) of vasopressin associated with pressure volume 2 under development
20) Confidence 0.81 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.55 Pain Relevance 0.09

General Comments

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