INT214005

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2007
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 74
Disease Relevance 29.40
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank2) plasma membrane (Ank2) cytoskeleton (Ank2)
cytoplasm (Ank2)
Anatomy Link Frequency
lung 6
cardiomyocytes 4
brain 4
skeletal muscle 3
spleen 3
Ank2 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 222 98.96 Very High Very High Very High
Catecholamine 74 98.56 Very High Very High Very High
imagery 74 98.24 Very High Very High Very High
anesthesia 74 88.68 High High
sodium channel 148 59.04 Quite High
Disease Link Frequency Relevance Heat
Aging 1554 100.00 Very High Very High Very High
Syndrome 592 100.00 Very High Very High Very High
Malaria 74 99.40 Very High Very High Very High
Disease 74 98.72 Very High Very High Very High
Diabetes Mellitus 74 98.40 Very High Very High Very High
Arrhythmia Under Development 1628 98.28 Very High Very High Very High
Kyphosis 148 98.24 Very High Very High Very High
Myocardial Infarction 518 98.20 Very High Very High Very High
Bradycardia 222 97.68 Very High Very High Very High
Neurological Disease 74 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resistance to malaria is an unlikely factor, since ankyrin-B is not expressed in erythrocytes (not shown), or in vascular endothelial cells (Figure S2), and since variants are present in both Africans and Europeans.
Neg (not) Gene_expression (expressed) of ankyrin-B in endothelial cells associated with malaria
1) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.53 Pain Relevance 0
Ankyrin-B also is present at detectable levels in skeletal muscle, kidney, lung, testes, spleen and lung, and is reduced about 50 percent in all of these tissues in ankyrin-B+/?
Gene_expression (present) of Ankyrin-B in skeletal muscle
2) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.34 Pain Relevance 0.03
We next determined the cell types expressing ankyrin-B in several tissues.
Gene_expression (expressing) of ankyrin-B
3) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.25 Pain Relevance 0.07
The high levels of ankyrin-B expression in the brain and pancreatic beta cells and early senescence in ankyrin-B+/?
Gene_expression (expression) of ankyrin-B in pancreatic beta cells associated with aging
4) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.89 Pain Relevance 0
neonatal cardiomyocytes can be rescued by expression of wild-type human ankyrin-B but not by ankyrin-B with variants associated with cardiac arrhythmia [13], [14], [18].
Gene_expression (expression) of ankyrin-B in cardiomyocytes associated with arrhythmia under development
5) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.12 Pain Relevance 0.04
In the pancreas, ankyrin-B is highly expressed in islets and is virtually absent from surrounding acinar cells (Figure 5C).
Neg (absent) Gene_expression (expressed) of ankyrin-B in acinar cells
6) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.19 Pain Relevance 0.08
Na/K ATPase expression and localization at sarcolemmal and intercalated disc membranes is unaffected in ankyrin-B+/?
Gene_expression (/) of ankyrin-B
7) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0 Pain Relevance 0
Results with ankyrin-B+/?
Gene_expression (/) of ankyrin-B
8) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.89 Pain Relevance 0
Together these findings suggest a constellation of traits that we term “ankyrin-B syndrome”, which may contribute to both aging-related disorders and enhanced cardiac function.


Gene_expression (syndrome) of ankyrin-B associated with aging and syndrome
9) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.76 Pain Relevance 0
It will be of interest in the future to screen larger populations from Ghana as well as African Americans to determine if homozygous L1622I individuals exist, and if so whether they exhibit features of ankyrin-B syndrome characterized so far in mice.
Gene_expression (syndrome) of ankyrin-B associated with syndrome
10) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.44 Pain Relevance 0
In contrast, ankyrin-B+/?
Gene_expression (/) of ankyrin-B
11) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0 Pain Relevance 0
Freshly isolated cardiomyocytes from ankyrin-B+/?
Gene_expression (/) of ankyrin-B in cardiomyocytes
12) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0 Pain Relevance 0
16%) in ankyrin-B+/?
Gene_expression (/) of ankyrin-B
13) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.06 Pain Relevance 0
Specifically, ankyrin-B+/?
Gene_expression (/) of ankyrin-B
14) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.63 Pain Relevance 0
The high levels of ankyrin-B expression in the brain and pancreatic beta cells and early senescence in ankyrin-B+/?
Gene_expression (senescence) of ankyrin-B in pancreatic beta cells associated with aging
15) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.89 Pain Relevance 0
As discussed later, ankyrin-B+/?
Gene_expression (/) of ankyrin-B
16) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.18 Pain Relevance 0
Studies with ankyrin-B+/?
Gene_expression (/) of ankyrin-B
17) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.04 Pain Relevance 0.11
Ankyrin-B immunostaining in ?
Gene_expression (immunostaining) of Ankyrin-B
18) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.11 Pain Relevance 0.10
One hypothesis to explain this phenotype is that disordered calcium homeostasis as observed in ankyrin-B+/?
Gene_expression (observed) of ankyrin-B
19) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.50 Pain Relevance 0
Following TAC for seven days that induced similar increases in LV pressure overload as measured by the trans-stenotic gradient (see Figure 2E), ankyrin-B+/?
Gene_expression (/) of ankyrin-B
20) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.20 Pain Relevance 0

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