INT214007

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.63
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank2) plasma membrane (Ank2) cytoskeleton (Ank2)
cytoplasm (Ank2)
Ank2 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 15 96.84 Very High Very High Very High
imagery 5 95.60 Very High Very High Very High
Catecholamine 5 79.72 Quite High
sodium channel 10 40.20 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 35 97.40 Very High Very High Very High
Aging 105 96.96 Very High Very High Very High
Arrhythmia Under Development 110 92.40 High High
Stress 10 91.32 High High
Syndrome 40 88.80 High High
Sudden Death 15 83.88 Quite High
Malaria 5 77.00 Quite High
Bradycardia 15 71.64 Quite High
Disease 5 64.40 Quite High
Death 40 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, both ankyrin-B and IP3 receptors are reduced in these cells in ankyrin-B+/?
Negative_regulation (reduced) of ankyrin-B
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.55 Pain Relevance 0
It will be important to evaluate effects of ankyrin-B deficiency and loss-of-function variants on mitochondrial function.
Negative_regulation (deficiency) of ankyrin-B
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.45 Pain Relevance 0
A striking and highly penetrant effect of ankyrin-B deficiency in the mouse is a moderate reduction in life span accompanied by premature senescence in multiple tissues.
Negative_regulation (deficiency) of ankyrin-B associated with aging
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.50 Pain Relevance 0
Loss of additional signaling molecules from ankyrin-B+/?
Negative_regulation (Loss) of ankyrin-B
4) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 1.02 Pain Relevance 0.04
-cells is significantly reduced in ankyrin-B+/?
Negative_regulation (reduced) of ankyrin-B
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.11 Pain Relevance 0.10

General Comments

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