INT214008

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank1) plasma membrane (Ank1) cytoskeleton (Ank1)
nucleus (Ank1) cytoplasm (Ank1)
Anatomy Link Frequency
thymus 1
Ank1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 6 88.40 High High
Catecholamine 3 46.48 Quite Low
long-term potentiation 23 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 3 97.88 Very High Very High Very High
Alopecia 9 95.32 Very High Very High Very High
Arrhythmia Under Development 66 94.68 High High
Aging 63 93.36 High High
Heart Arrhythmia 3 92.36 High High
Myocardial Infarction 21 71.60 Quite High
Syndrome 39 67.28 Quite High
Spherocytosis 3 67.16 Quite High
Stress 6 65.92 Quite High
Bradycardia 9 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We do note that a de novo mutation in the ankyrin repeat domain has been reported in a child with an ASD [27], providing strong support for a role for loss of the longer ankyrin repeat domain-containing form in neurodevelopmental disabilities.
Negative_regulation (loss) of ankyrin
1) Confidence 0.03 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0
Loss of ankyrin-G function thus would likely have major consequences beginning in early development.
Negative_regulation (Loss) of ankyrin
2) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.81 Pain Relevance 0.09
However, since ankyrin-B is also expressed in thymus [35], an alternative hypothesis is that reduced ankyrin function in thymus results in reduced resistance to infection or even potential auto-immune defects associated with hair loss.
Negative_regulation (reduced) of ankyrin in thymus associated with alopecia and infection
3) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.50 Pain Relevance 0
In the European population, all SNPs had an allele frequency of less than 0.01, though combined, 2.1% of the European sample had a loss of function ankyrin B variant.
Negative_regulation (loss) of ankyrin
4) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2013943 Disease Relevance 0.17 Pain Relevance 0

General Comments

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