INT214045

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1)
hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)
Anatomy Link Frequency
Caco-2 1
brains 1
OGG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 8 50.00 Quite Low
carpal tunnel syndrome 2 38.56 Quite Low
Pain 2 30.80 Quite Low
Inflammation 17 23.12 Low Low
ischemia 11 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 24 99.92 Very High Very High Very High
Disease 166 99.48 Very High Very High Very High
Tuberous Sclerosis 11 95.52 Very High Very High Very High
Genomic Instability 3 93.60 High High
Apoptosis 57 86.12 High High
Acromegaly 10 84.72 Quite High
Stress 77 80.56 Quite High
Cognitive Disorder 37 80.32 Quite High
Cancer 27 76.16 Quite High
Diabetes Mellitus 17 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this study demonstrates significant BER dysfunction in brains of AD patients, resulting from reduced UDG, OGG1 and pol ?
Negative_regulation (reduced) of OGG1 in brains associated with disease
1) Confidence 0.36 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.96 Pain Relevance 0
As well illustrated in Figure 8, treatment with FE/ASC resulted in a significant (P<0.001) reduction of OGG1 mRNA and protein mass compared with controls.
Negative_regulation (reduction) of OGG1
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.05 Pain Relevance 0
Deficiency in DNA repair enzyme OGG1 has likely important functional consequences, compromising the ability of cells to repair DNA.
Negative_regulation (Deficiency) of OGG1
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.37 Pain Relevance 0
The present study shows that incubation of Caco-2/15 with FE/ASC resulted in a marked decrease in OGG1 transcript level and protein mass.
Negative_regulation (decrease) of OGG1 in Caco-2
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.37 Pain Relevance 0
Loss of tuberin is accompanied by the loss of OGG1 contributing to tumourgenesis [99].


Negative_regulation (loss) of OGG1
5) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.72 Pain Relevance 0
Treatment for adult-onset GH (A-OGH) deficiency should be stopped only when the patient and the patientÂ’s physician consider it appropriate.
Negative_regulation (deficiency) of A-OGH
6) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.30 Pain Relevance 0
A-OGH deficiency reduces psychological well-being and quality of life (QoL) (Stabler et al 1992; Rosen et al 1994).
Negative_regulation (deficiency) of A-OGH
7) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.71 Pain Relevance 0

General Comments

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