INT214045

Context Info Confidence 0.36 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 7 Disease Relevance 3.49 Pain Relevance 0

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1) hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)

Anatomy Link Frequency Caco-2 1 brains 1 OGG1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory marker 8 50.00 carpal tunnel syndrome 2 38.56 Pain 2 30.80 Inflammation 17 23.12 ischemia 11 5.00 cytokine 4 5.00 imagery 4 5.00 Central nervous system 3 5.00 alcohol 3 5.00 cINOD 3 5.00

Disease Link Frequency Relevance Heat Cardiovascular Disease 24 99.92 Disease 166 99.48 Tuberous Sclerosis 11 95.52 Genomic Instability 3 93.60 Apoptosis 57 86.12 Acromegaly 10 84.72 Stress 77 80.56 Cognitive Disorder 37 80.32 Cancer 27 76.16 Diabetes Mellitus 17 75.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In summary, this study demonstrates significant BER dysfunction in brains of AD patients, resulting from reduced UDG, OGG1 and pol ?

Negative_regulation (reduced) of OGG1 in brains associated with disease

1) Confidence 0.36 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC2018628 Disease Relevance 0.96 Pain Relevance 0

As well illustrated in Figure 8, treatment with FE/ASC resulted in a significant (P<0.001) reduction of OGG1 mRNA and protein mass compared with controls.

Negative_regulation (reduction) of OGG1

2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.05 Pain Relevance 0

Deficiency in DNA repair enzyme OGG1 has likely important functional consequences, compromising the ability of cells to repair DNA.

Negative_regulation (Deficiency) of OGG1

3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.37 Pain Relevance 0

The present study shows that incubation of Caco-2/15 with FE/ASC resulted in a marked decrease in OGG1 transcript level and protein mass.

Negative_regulation (decrease) of OGG1 in Caco-2

4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.37 Pain Relevance 0

Loss of tuberin is accompanied by the loss of OGG1 contributing to tumourgenesis [99].

Negative_regulation (loss) of OGG1

5) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.72 Pain Relevance 0

Treatment for adult-onset GH (A-OGH) deficiency should be stopped only when the patient and the patient’s physician consider it appropriate.

Negative_regulation (deficiency) of A-OGH

6) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.30 Pain Relevance 0

A-OGH deficiency reduces psychological well-being and quality of life (QoL) (Stabler et al 1992; Rosen et al 1994).

Negative_regulation (deficiency) of A-OGH

7) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.71 Pain Relevance 0

General Comments

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