INT21406

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.36
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocyte 4
spinal cord 2
Peyer's patch 2
CII 2
T-cell 2
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 40 100.00 Very High Very High Very High
agonist 13 99.68 Very High Very High Very High
antagonist 24 99.62 Very High Very High Very High
opioid receptor 5 99.52 Very High Very High Very High
Morphine 12 99.32 Very High Very High Very High
Arthritis 129 97.72 Very High Very High Very High
rheumatoid arthritis 281 97.40 Very High Very High Very High
anesthesia 7 96.04 Very High Very High Very High
cytokine 176 93.20 High High
ketamine 6 93.08 High High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 100 100.00 Very High Very High Very High
Proteinuria 19 99.72 Very High Very High Very High
Hyperplasia 8 98.88 Very High Very High Very High
Motor Neuron Diseases 36 98.84 Very High Very High Very High
Rhinitis 4 97.80 Very High Very High Very High
Arthritis 125 97.72 Very High Very High Very High
Cytomegalovirus Infection 10 97.72 Very High Very High Very High
Rheumatoid Arthritis 283 97.40 Very High Very High Very High
Disease 236 96.84 Very High Very High Very High
Renal Disease 70 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study of pregnant and lactating rats compared TN3 PEGylated FabÂ’ (comparable to certolizumab) and TN3 IgG1 antibody (comparable to the classic anti-TNF?
Negative_regulation (compared) of Gene_expression (antibody) of IgG1
1) Confidence 0.41 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971732 Disease Relevance 0.06 Pain Relevance 0.21
Morphine resulted in a highly significant inhibition of CT-specific IgA and IgG production in fragment culture supernatants of all three tissues compared with placebo.
Negative_regulation (inhibition) of Gene_expression (production) of IgG associated with morphine
2) Confidence 0.39 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11564781 Disease Relevance 0.31 Pain Relevance 0.89
Recently, IgG was detected in the perikarya of motor neurons of the lumbar spinal cord in mice 24 hours after intraperitoneal injection of IgG derived from sera of ALS patients [31].
Negative_regulation (injection) of Gene_expression (detected) of IgG in spinal cord associated with motor neuron diseases and spinal cord
3) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.78 Pain Relevance 0.24
Such a distribution between vaccine-specific IgG subclasses was not present in RTX-treated patients, suggesting that RTX disrupted the "normal subclass" pattern of IgG production.
Negative_regulation (disrupted) of Gene_expression (production) of IgG
4) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.37 Pain Relevance 0.04
However, half of the post-RTX patients showed a total absence of vaccine-specific IgG production in all subclasses.
Negative_regulation (absence) of Gene_expression (production) of IgG
5) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.41 Pain Relevance 0
Total absence of influenza-specific IgG production was observed in 55% of the post-RTX group.


Negative_regulation (absence) of Gene_expression (production) of IgG associated with influenza virus infection
6) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911904 Disease Relevance 0.83 Pain Relevance 0.21
Rituximab significantly reduced immunoglobulin production at the mRNA level, as well as total IgM and IgG content in synovia containing lymphoid aggregates, but not in synovia where lymphoid infiltration was diffuse.
Negative_regulation (reduced) of Gene_expression (production) of IgG
7) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.05 Pain Relevance 0.03
10) or 400 ng rabbit IgG/SAP conjugate (N?
Negative_regulation (rabbit) of Gene_expression (/) of IgG
8) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2519834 Disease Relevance 0 Pain Relevance 0.14
Furthermore, B7-H4Ig plasmid treatment suppressed the production of total IgG (Figure 5C) and IgG1, IgG2a, and IgG2b autoantibodies to CII (Figure S7).
Negative_regulation (suppressed) of Gene_expression (production) of IgG in CII
9) Confidence 0.15 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.67 Pain Relevance 0.29
Clinical improvement was associated with the reduction in productions of IgG anti-dsDNA autoantibodies with reduction of IFN-?
Negative_regulation (reduction) of Gene_expression (productions) of IgG
10) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.94 Pain Relevance 0
Determination of IgG and IgA antibodies in serum and BAL fluid
Negative_regulation (Determination) of Gene_expression (antibodies) of IgG
11) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2496893 Disease Relevance 0.07 Pain Relevance 0.12
This combined therapy in mice with intravenous injection dramatically delayed the onset of proteinuria, effectively inhibited IgG autoantibody production, and significantly reduced hypercellularity and deposition of IgG in glomeruli, resulting in almost complete amelioration of lupus nephritis in these animals.
Negative_regulation (inhibited) of Gene_expression (production) of IgG associated with renal disease, proteinuria and hyperplasia
12) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.94 Pain Relevance 0
A modest decrease in total anticollagen IgG levels was observed.
Negative_regulation (decrease) of Gene_expression (levels) of IgG
13) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.60 Pain Relevance 0.10
The inability of infected individuals to produce long-lasting amounts of antigen-specific IgG Abs and the levels of antigenic variation displayed by the parasites impose major difficulties that prevent immune intervention against trypanosomosis.
Negative_regulation (amounts) of Gene_expression (produce) of IgG
14) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.32 Pain Relevance 0
This was confirmed in the present study, which demonstrated a high prevalence (71%) of IgG titres ?
Negative_regulation (prevalence) of Gene_expression (titres) of IgG
15) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699976 Disease Relevance 0.95 Pain Relevance 0
Treatment with mycophenolate mofetil reduces rheumatoid factor titres, immunoglobulin (IgG, IgM, and IgA) levels, and the total number of T cells (CD2) in RA patient peripheral blood; in addition, lymphocyte mitogen responses are inhibited and delayed hypersensitivity skin test reactivity is decreased.
Negative_regulation (reduces) of Gene_expression (titres) of IgG in lymphocyte associated with hypersensitivity and rheumatoid arthritis
16) Confidence 0.05 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324935 Disease Relevance 1.06 Pain Relevance 0.31
Oxymorphindole, a delta class opioid receptor agonist, significantly decreased IgM but not IgA or IgG production by the mitogen-stimulated Peyer's patch lymphocytes.
Neg (not) Negative_regulation (decreased) of Gene_expression (production) of IgG in lymphocytes associated with agonist and opioid receptor
17) Confidence 0.03 Published 1990 Journal Life Sci. Section Abstract Doc Link 2172675 Disease Relevance 0.07 Pain Relevance 0.42
We have found beta-endorphin, ACTH, and naltrindole (delta-class opioid receptor antagonist) to significantly suppress concanavalin A-stimulated Peyer's patch lymphocyte immunoglobulin production of IgA, IgG, and IgM isotypes.
Negative_regulation (suppress) of Gene_expression (production) of IgG in Peyer's patch associated with antagonist and opioid receptor
18) Confidence 0.03 Published 1990 Journal Life Sci. Section Abstract Doc Link 2172675 Disease Relevance 0.06 Pain Relevance 0.42
Immunological evaluation demonstrated the following: IgG levels were slightly decreased, but IgG subclass levels were all normal.
Negative_regulation (decreased) of Gene_expression (levels) of IgG
19) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.50 Pain Relevance 0.03
It binds to dihydro-orotate dehydrogenase and inhibits de novo pyrimidine biosynthesis, thus blocking B- and T-cell proliferation and also strongly suppresses IgG and IgM antibody production [124] It possesses antiviral properties and can inhibit cytomegalovirus and polyoma virus replication in vitro [125].
Negative_regulation (suppresses) of Gene_expression (production) of IgG in T-cell associated with cytomegalovirus infection
20) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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