INT214067

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 12.48
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib)
cytoplasm (Scrib)
Anatomy Link Frequency
liver 2
epithelial cells 1
Scrib (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 28 93.68 High High
Bioavailability 2 92.96 High High
Inflammation 52 84.52 Quite High
agonist 60 78.24 Quite High
withdrawal 7 39.00 Quite Low
chemokine 2 30.24 Quite Low
COX-2 inhibitor 7 14.08 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 594 100.00 Very High Very High Very High
Colorectal Cancer 169 100.00 Very High Very High Very High
Metastasis 242 99.96 Very High Very High Very High
Familial Adenomatous Polyposis 258 99.76 Very High Very High Very High
Cancer 448 98.98 Very High Very High Very High
INFLAMMATION 58 93.28 High High
Adenoma 69 92.64 High High
Adenocarcinoma 13 91.76 High High
Death 16 80.76 Quite High
Esophageal Cancer 1 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously described in detail the inhibitory effect of pharmacological blockade of the RAS on CRC liver metastases.
Regulation (effect) of CRC in liver associated with colon cancer and metastasis
1) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.35 Pain Relevance 0
However, in the liver surrounding CRC metastases treatment with captopril resulted in significantly lower angiotensinogen mRNA expression at almost all time points compared to both the sham and control tumor-induced liver (P ?
Regulation (surrounding) of CRC in liver associated with cancer, colon cancer and metastasis
2) Confidence 0.18 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.18 Pain Relevance 0
At day 16 MasR mRNA expression also increased in tumors with captopril treatment (P = 0.0299) compared to control CRC metastases (Figure 2).
Regulation (control) of CRC associated with cancer, colon cancer and metastasis
3) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.62 Pain Relevance 0
The first group was composed by individuals exhibiting genotype 0 for the N SNPs, i.e., carrying the frequent allele at homozygous state for the N SNPs; this group, theoretically the most frequent group in the study cohort, was set as a reference, and the relating combination of genotypes was considered as the "reference pattern" exhibiting a null or very weak effect on CRC risk.
Regulation (effect) of CRC associated with colon cancer
4) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.36 Pain Relevance 0
-catenin, which suggests that this function is important for the pathogenesis of CRC.
Regulation (important) of CRC associated with colon cancer
5) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.97 Pain Relevance 0
Inactivation of the APC protein is responsible for both inherited and sporadic types of CRC.
Regulation (responsible) of CRC associated with colorectal cancer and familial adenomatous polyposis
6) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.44 Pain Relevance 0
A protective effect on CRC risk had been reported for the rare allele of variant PPARG c.36C>G (p.Pro12Ala) [49,50], but we were not able to reproduce this observation in our study population, perhaps because the reference studies were designed on smaller populations – about 200 case-control pairs-.
Regulation (effect) of CRC associated with colon cancer
7) Confidence 0.03 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.90 Pain Relevance 0.04
Interestingly, indomethacin down-regulates the expression of some of the ABC transporters, which are up regulated in CRC [38,41].
Regulation (regulated) of CRC associated with colorectal cancer
8) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.73 Pain Relevance 0.09
In particular, the mechanisms and signal pathways of pre-neoplastic colorectal epithelial cells are of special interest as these could be target for pharmacotherapy in the prevention of colorectal neoplasia (CRN) and CRC.
Regulation (target) of CRC in epithelial cells associated with colorectal cancer
9) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.09 Pain Relevance 0.19
Instead, we observed a profound dysregulation of the retinoid pathway in this CRC.
Regulation (dysregulation) of CRC associated with colon cancer
10) Confidence 0.01 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.94 Pain Relevance 0
The strictly concentration-dependent effects of PGE2 documented herein strongly argue for two counter-regulatory effects of low versus high PGE2 doses on the regulation of CRC cell growth.
Regulation (regulation) of CRC associated with colon cancer
11) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.90 Pain Relevance 0.14

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