INT214095

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 30 99.76 Very High Very High Very High
Central nervous system 45 97.20 Very High Very High Very High
agonist 30 86.64 High High
Glutamate 3 84.56 Quite High
gABA 24 61.36 Quite High
amygdala 24 34.88 Quite Low
Action potential 12 19.52 Low Low
medulla 81 5.00 Very Low Very Low Very Low
Cholecystokinin 24 5.00 Very Low Very Low Very Low
vagus nerve 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 30 98.80 Very High Very High Very High
Anorexia 42 91.72 High High
Obesity 171 80.16 Quite High
Generalized Anxiety Disorder 6 59.16 Quite High
Targeted Disruption 6 26.36 Quite Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low
Weight Gain 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior administration of the MC3R/MC4R antagonist SHU9119 abolishes nesfatin-1-induced feeding suppression, but nesfatin-1 does not show any direct agonistic action on MC3R or MC4R.
MC3R Binding (administration) of associated with appetite loss and antagonist
1) Confidence 0.32 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.05
Both AgRP and the MSHs can bind to MC3R and MC4R either presynaptically or postsynaptically [10,11].
MC3R Binding (bind) of
2) Confidence 0.30 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.36
Whilst not being shown to activate hypothalamic neurones in vivo [42], it binds to and activates both MC3R and MC4R in vitro and has an anorectic effect at high doses in vivo [123].
MC3R Binding (binds) of associated with appetite loss
3) Confidence 0.30 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.30 Pain Relevance 0

General Comments

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