INT214105

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neuronal 2
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 35 98.00 Very High Very High Very High
Cannabinoid 33 74.84 Quite High
Thalamus 2 62.88 Quite High
Locus ceruleus 2 60.88 Quite High
vagus nerve 7 59.28 Quite High
medulla 27 58.40 Quite High
agonist 12 41.44 Quite Low
Action potential 5 32.96 Quite Low
antagonist 26 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperphagia 3 94.20 High High
Body Weight 4 64.48 Quite High
Stress 4 54.60 Quite High
Targeted Disruption 5 24.88 Low Low
Obesity 57 5.00 Very Low Very Low Very Low
Appetite Loss 16 5.00 Very Low Very Low Very Low
Anorexia 14 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, CB1 activation stimulates NPY release [28] therefore a positive feed-back loop between endocannabinoids and ghrelin-induced NPY would partly explain the lack of effect in CB1-KO animals.
Positive_regulation (stimulates) of Localization (release) of NPY associated with endocannabinoid
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.38
This is achieved in part by altering the balance of neuronal activity, favouring NPY/AgRP release and reducing ?
Positive_regulation (favouring) of Localization (release) of NPY in neuronal
2) Confidence 0.31 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

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