INT214111

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.81
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
nucleus 1
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 111 99.52 Very High Very High Very High
cytokine 30 98.16 Very High Very High Very High
Inflammatory marker 12 93.08 High High
melanocortin 1 receptor 9 78.36 Quite High
agonist 22 68.44 Quite High
antagonist 16 66.76 Quite High
Action potential 4 65.20 Quite High
Inflammatory stimuli 12 62.80 Quite High
medulla 27 52.20 Quite High
vagus nerve 7 51.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 135 99.52 Very High Very High Very High
Appetite Loss 10 92.64 High High
Stress 10 86.24 High High
Targeted Disruption 2 69.00 Quite High
Overweight 3 56.72 Quite High
Obesity 90 51.16 Quite High
Body Weight 18 35.48 Quite Low
Hyperphagia 3 24.20 Low Low
Dementia 3 14.08 Low Low
Anorexia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that sensitization of the MC3R and expression, indirectly regulated by proinflammatory cytokine production acutely during and following an exercise bout, may be linked to the reductions in circulating inflammatory markers observed in other exercise studies [2].
Localization (sensitization) of MC3R associated with inflammatory marker and cytokine
1) Confidence 0.72 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.29 Pain Relevance 0.31
The MC3R-induced secretion of IL-10 underscores the potential importance of MC3R as an anti-inflammatory modulator due to the ability of IL-10 to inhibit inflammatory cytokines, including IL-6, TNF-?
Localization (importance) of MC3R associated with inflammation and cytokine
2) Confidence 0.72 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.70 Pain Relevance 0.46
The MC3R-induced secretion of IL-10 underscores the potential importance of MC3R as an anti-inflammatory modulator due to the ability of IL-10 to inhibit inflammatory cytokines, including IL-6, TNF-?
Localization (importance) of MC3R associated with inflammation and cytokine
3) Confidence 0.72 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.65 Pain Relevance 0.46
Using techniques already described in this article, there is evidence of POMC projections from the arcuate nucleus to the DMH (Table 1; [93]) and both mc3r and mc4r mRNA are found in this nucleus (Table 3; [90,118]).
Localization (found) of mc3r in nucleus
4) Confidence 0.63 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.16 Pain Relevance 0.11

General Comments

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