INT214113

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
nucleus 1
tail vein 1
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 10 99.68 Very High Very High Very High
Pain 18 98.72 Very High Very High Very High
Neuropathic pain 8 97.08 Very High Very High Very High
Root ganglion neuron 4 92.36 High High
Dorsal horn 8 90.96 High High
Somatostatin 4 87.92 High High
Inflammation 22 59.20 Quite High
Central nervous system 17 57.64 Quite High
Nucleus accumbens 5 37.60 Quite Low
amygdala 8 35.52 Quite Low
Disease Link Frequency Relevance Heat
Pain 22 98.72 Very High Very High Very High
Neuropathic Pain 14 97.08 Very High Very High Very High
Hypersensitivity 28 94.56 High High
Anorexia 14 94.24 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 93.36 High High
Weight Gain 4 92.92 High High
Ganglion Cysts 4 92.04 High High
Obesity 57 91.52 High High
Down Syndrome 2 76.04 Quite High
Death 2 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, we examined trkB.T1 mRNA expression in the spinal dorsal horn of a mouse model of antiretroviral-associated neuropathic pain [36], a model in which significant mechanical hypersensitivity occurs one day after tail vein injection with stavudine (d4T) [37].
Spec (examined) Transcription (expression) of trkB in tail vein associated with spinal dorsal horn, hypersensitivity and neuropathic pain
1) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.79 Pain Relevance 0.39
At later time points (6 h, 12 h, 18 h, 3 d) trkB.T1 mRNA levels returned to saline control levels (data not shown).
Transcription (levels) of trkB
2) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.62 Pain Relevance 0.41
It is unlikely that BDNF modulates either CART/POMC or NPY/AgRP neurones in the arcuate nucleus as there is no trkb receptor mRNA expressed in this nucleus [170].


Neg (no) Transcription (expressed) of trkb in nucleus
3) Confidence 0.42 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.43 Pain Relevance 0.17

General Comments

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