INT214115

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.37
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
fat 2
cardiomyocyte 2
cartilage 2
immune system 2
adipose tissue 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 379 98.44 Very High Very High Very High
cytokine 77 97.76 Very High Very High Very High
Inflammatory mediators 6 97.24 Very High Very High Very High
tolerance 24 94.68 High High
metalloproteinase 6 94.20 High High
agonist 21 89.24 High High
Pain 81 70.48 Quite High
rheumatoid arthritis 9 68.32 Quite High
Inflammation 72 55.48 Quite High
Central nervous system 15 54.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 776 99.62 Very High Very High Very High
Aging 248 99.24 Very High Very High Very High
Osteoarthritis 314 98.44 Very High Very High Very High
INFLAMMATION 85 96.84 Very High Very High Very High
Impaired Glucose Tolerance 24 94.68 High High
Anorexia 14 92.48 High High
Cancer 11 92.24 High High
Necrosis 6 92.00 High High
Osteophyte 10 90.84 High High
Insulin Resistance 22 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is evidence that the regulation of leptin expression through environmental, genetic, or epigenetic factors may be responsible for influencing the production of proinflammatory mediators and matrix metalloproteinases in cartilage [47].
Regulation (regulation) of Gene_expression (expression) of leptin in cartilage associated with metalloproteinase
1) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.65 Pain Relevance 0.26
Depending on the level of exposure, leptin is known to elicit a paradoxical
                   effect on cardiomyocyte contractile function through either inhibition or
                   stimulation of O2? 
Regulation (Depending) of Gene_expression (known) of leptin in cardiomyocyte
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.65 Pain Relevance 0
production plays a role
                   in the disparate leptin effects between young and aging ob/ob
                   mice, we evaluated O2? 
Regulation (role) of Gene_expression (effects) of leptin associated with aging
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.60 Pain Relevance 0
On the other hand, increased leptin levels are associated with increased concentrations of other proinflammatory cytokines such as IL-1, IL-6, IL-8, TNF?
Regulation (associated) of Gene_expression (levels) of leptin associated with cytokine
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.79 Pain Relevance 0.54
The addition of leptin had no affect on [3H]proline incorporation rates, indicating that leptin does not synergistically mediate IL-1?
Neg (no) Regulation (affect) of Gene_expression (addition) of leptin
5) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.06 Pain Relevance 0.03
The overall leptin action in the immune system is a proinflammatory effect, activating proinflammatory cells, promoting T-helper 1 responses, and mediating the production of the other proinflammatory cytokines, such as tumor necrosis factor-?
Regulation (overall) of Gene_expression (action) of leptin in immune system associated with necrosis, cancer and cytokine
6) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.40 Pain Relevance 0.12
-cell proliferation in vivo (Rane et al., 1999), was up-regulated 50% in ob/ob islets, and Ki67 immunostaining showed a significant increase in ?
Regulation (regulated) of Gene_expression (islets) of ob
7) Confidence 0.39 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.66 Pain Relevance 0
-cell proliferation in vivo (Rane et al., 1999), was up-regulated 50% in ob/ob islets, and Ki67 immunostaining showed a significant increase in ?
Regulation (regulated) of Gene_expression (islets) of ob
8) Confidence 0.39 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.66 Pain Relevance 0
Furthermore, we found that the associations in women between hip JSN and BMI, fat mass, and WHR were dependent on serum leptin levels, but not on serum IL-6 levels.
Neg (not) Regulation (dependent) of Gene_expression (levels) of serum leptin in fat associated with obesity
9) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.68 Pain Relevance 0.23
Others have found that there is virtually no change in hypothalamic pomc expression in either food restricted, fasted or leptin resistant (Zucker) rats versus controls [70].
Neg (no) Regulation (change) of Gene_expression (expression) of leptin
10) Confidence 0.19 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.26 Pain Relevance 0.11
in the control of glucose homeostasis expands beyond its primary action in adipose tissue, and involves the regulation of adipocytokine production such as adiponectin, leptin, and resistin [19]–[21].
Regulation (regulation) of Gene_expression (production) of leptin in adipose tissue associated with obesity
11) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.97 Pain Relevance 0.15

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