INT214122

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.59
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
nerve 1
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
melanocortin 1 receptor 70 98.96 Very High Very High Very High
Inflammation 117 98.16 Very High Very High Very High
Spinal cord 4 94.84 High High
Glutamate 2 94.44 High High
Inflammatory response 13 90.44 High High
Central nervous system 31 88.24 High High
agonist 57 76.32 Quite High
chemokine 22 74.28 Quite High
Neuropathic pain 7 73.28 Quite High
Disease Link Frequency Relevance Heat
Obesity 118 99.24 Very High Very High Very High
Hyperphagia 6 98.20 Very High Very High Very High
INFLAMMATION 126 98.16 Very High Very High Very High
Injury 32 96.04 Very High Very High Very High
Nervous System Injury 2 95.76 Very High Very High Very High
Sprains And Strains 24 91.36 High High
Adhesions 30 88.64 High High
Anorexia 28 78.08 Quite High
Appetite Loss 20 74.96 Quite High
Neuropathic Pain 22 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene deficiency in MC3R produced remarkable augmentation of the cellular responses in the mesenteric microcirculation after I/R; this was particularly consistent at the 90 min time point as shown here and as evident at other time points as well (we have tested up to 4 h postreperfusion; unpublished results).
Negative_regulation (deficiency) of MC3R
1) Confidence 0.43 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.91 Pain Relevance 0.43
In contrast, the I/R procedure augmented circulating nitrite/nitrate levels, with a more marked response in MC3R-null mice, with values significantly different from WT animals for the I/R groups (P<0.05; Fig. 4D).


Negative_regulation (response) of MC3R-null
2) Confidence 0.42 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.15 Pain Relevance 0.06
However, mice lacking both mc3r and mc4r are more obese than mc4r ko mice alone [112,113].
Negative_regulation (lacking) of mc3r associated with obesity
3) Confidence 0.37 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 1.15 Pain Relevance 0.19
Following axotomy, no alteration in MC1R mRNA expression is seen in dorsal root ganglia and decreases in both MC2R and MC3R, but MC4R mRNA increases following axotomy [48], perhaps suggesting a greater role for MC4R than MC1R in nerve injury.
Negative_regulation (decreases) of MC3R in nerve associated with nervous system injury and melanocortin 1 receptor
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.08 Pain Relevance 1.06
AgRP – more than an antagonist of MC4R and MC3R?
Negative_regulation (antagonist) of MC3R associated with antagonist
5) Confidence 0.32 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.30 Pain Relevance 0.40

General Comments

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