INT214123

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.52
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
SLD 2
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 19 100.00 Very High Very High Very High
GABAergic 47 99.98 Very High Very High Very High
Glutamate 8 89.52 High High
Central grey 8 83.76 Quite High
antagonist 12 82.72 Quite High
GABA receptor 2 79.60 Quite High
nMDA receptor 2 74.72 Quite High
Neurotransmitter 4 73.24 Quite High
Raphe 3 70.48 Quite High
Locus ceruleus 10 66.24 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 46 100.00 Very High Very High Very High
Epilepsy 6 99.76 Very High Very High Very High
Sleep Disorders 18 99.60 Very High Very High Very High
Convulsion 84 98.40 Very High Very High Very High
Obesity 57 91.48 High High
Autoimmune Disease 134 90.08 High High
Urological Neuroanatomy 12 83.76 Quite High
Anorexia 14 83.64 Quite High
Targeted Disruption 4 80.52 Quite High
Vibrio Infection 1 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, Lu et al. [4] showed that part of the SLD PS-on neurons could be GABAergic combining GAD and Fos staining after PS hypersomnia.
Negative_regulation (combining) of Gene_expression (staining) of GAD in SLD associated with generalized anxiety disorder, gabaergic and sleep disorders
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.55 Pain Relevance 0.53
For instance, the presence of autoantibody to GAD was demonstrated in the sera of non-fragile X patients with early onset of chronic drug-resistant epilepsy leading to loss of GAD and decreased GABA synthesis that ultimately contributed to a lower seizure threshold (McKnight et al. 2005).
Negative_regulation (decreased) of Gene_expression (synthesis) of GAD associated with epilepsy, gaba, convulsion and generalized anxiety disorder
2) Confidence 0.04 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.71 Pain Relevance 0.29
For instance, the presence of autoantibody to GAD was demonstrated in the sera of non-fragile X patients with early onset of chronic drug-resistant epilepsy leading to loss of GAD and decreased GABA synthesis that ultimately contributed to a lower seizure threshold (McKnight et al. 2005).
Negative_regulation (loss) of Gene_expression (synthesis) of GAD associated with epilepsy, gaba, convulsion and generalized anxiety disorder
3) Confidence 0.04 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.72 Pain Relevance 0.29
Also, approximately one-third of POMC/CART neurones express glutamic acid decarboxylase (GAD) mRNA [47].
Negative_regulation (neurones) of Gene_expression (express) of GAD associated with generalized anxiety disorder
4) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.41

General Comments

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