INT214124

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
amygdala 8 34.88 Quite Low
agonist 10 24.80 Low Low
medulla 27 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Cholecystokinin 8 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
vagus nerve 7 5.00 Very Low Very Low Very Low
Nucleus accumbens 5 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 10 99.20 Very High Very High Very High
Anorexia 14 91.72 High High
Obesity 57 27.76 Quite Low
Targeted Disruption 2 26.36 Quite Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Hyperphagia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior administration of the MC3R/MC4R antagonist SHU9119 abolishes nesfatin-1-induced feeding suppression, but nesfatin-1 does not show any direct agonistic action on MC3R or MC4R.
Negative_regulation (abolishes) of MC4R Binding (administration) of associated with appetite loss and antagonist
1) Confidence 0.42 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

This test has worked.

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