INT214131

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.43
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
leukocytes 1
mononuclear cells 1
mononuclear phagocytes 1
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 66 99.96 Very High Very High Very High
medulla 27 91.80 High High
vagus nerve 7 81.68 Quite High
Cholecystokinin 8 81.12 Quite High
Inflammation 196 79.76 Quite High
Inflammatory response 24 74.44 Quite High
Endogenous opioid 2 72.76 Quite High
antagonist 10 71.04 Quite High
ischemia 24 70.68 Quite High
parabrachial 1 64.16 Quite High
Disease Link Frequency Relevance Heat
Adhesions 60 99.28 Very High Very High Very High
Body Weight 7 89.44 High High
INFLAMMATION 212 79.76 Quite High
Anorexia 14 79.12 Quite High
Injury 28 78.32 Quite High
Urological Neuroanatomy 16 76.60 Quite High
Cv Unclassified Under Development 24 70.68 Quite High
Obesity 57 24.40 Low Low
Colitis 4 17.48 Low Low
Sprains And Strains 13 10.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunocytochemistry to demonstrate both POMC and AgRP fibres and in situ hybridisation to show their MC4R and MC3R targets (Table 3), much of the neuroanatomy of the melanocortin system has been mapped [93].
Regulation (targets) of MC3R
1) Confidence 0.52 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.17 Pain Relevance 0.95
To investigate the possible effects of MC3R gene ablation on adhesion molecule expression on circulating leukocytes during I/R, we investigated the expression of CD11b and CD62L on granulocytes (GR-1hi) and mononuclear phagocytes (F4/80+).
Spec (possible) Regulation (effects) of MC3R in mononuclear phagocytes associated with adhesions
2) Confidence 0.45 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0.03
However, what would be the source of MC3R agonists?
Regulation (source) of MC3R associated with agonist
3) Confidence 0.39 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.38 Pain Relevance 0.19
Immunocytochemistry revealed that white blood cells, such as PMN leukocytes and mononuclear cells, were positive for both MC1R and MC3R protein expression (Fig. 1B); nobably, no MC3R immunoreactivity was detected in tissue cells of MC3R-null mice.
Neg (no) Regulation (immunoreactivity) of MC3R in mononuclear cells
4) Confidence 0.27 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.31 Pain Relevance 0.04
Immunocytochemistry revealed that white blood cells, such as PMN leukocytes and mononuclear cells, were positive for both MC1R and MC3R protein expression (Fig. 1B); nobably, no MC3R immunoreactivity was detected in tissue cells of MC3R-null mice.
Neg (no) Regulation (immunoreactivity) of MC3R in leukocytes
5) Confidence 0.09 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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