INT214132

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nucb2) endoplasmic reticulum (Nucb2) nucleus (Nucb2)
DNA binding (Nucb2) cytoplasm (Nucb2)
Nucb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 11 78.20 Quite High
antagonist 10 70.24 Quite High
Bile 16 66.68 Quite High
amygdala 8 49.48 Quite Low
medulla 27 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Cholecystokinin 8 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
vagus nerve 7 5.00 Very Low Very Low Very Low
Nucleus accumbens 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anorexia 14 95.00 High High
Obesity 74 90.52 High High
Targeted Disruption 39 73.20 Quite High
Appetite Loss 10 66.40 Quite High
Weight Gain 5 29.80 Quite Low
Disease 6 13.92 Low Low
Extrahepatic Cholestasis 1 8.16 Low Low
Pancreatic Cancer 1 5.20 Low Low
Rickets 18 5.00 Very Low Very Low Very Low
Metabolic Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, although hepatic Fgf21 expression is greatly induced in wild-type mice by fasting for 24 h, serum NEFA levels are essentially unchanged (Badman et al. 2007; Hotta et al. 2009).
Neg (unchanged) Regulation (unchanged) of NEFA
1) Confidence 0.04 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.16 Pain Relevance 0.10
Also, the satiety effect of nesfatin-1 is not altered in Zucker rats with an leprb mutation and prior administration of an anti-nesfatin-1 antibody does not block leptin-induced anorexia.
Neg (not) Regulation (altered) of nesfatin-1 associated with anorexia
2) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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