INT214136

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.59
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DST) endoplasmic reticulum (DST) cytoplasm (DST)
cell adhesion (DST) cell motility (DST) nucleus (DST)
Anatomy Link Frequency
endothelial cell 1
nucleus 1
DST (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 96.72 Very High Very High Very High
amygdala 8 95.84 Very High Very High Very High
Neurotransmitter 2 93.44 High High
medulla 29 88.08 High High
Central nervous system 18 67.60 Quite High
Inflammation 22 63.92 Quite High
Spinal cord 19 55.40 Quite High
Neuropathic pain 10 50.00 Quite Low
Inflammatory marker 2 49.92 Quite Low
antagonist 16 17.44 Low Low
Disease Link Frequency Relevance Heat
Aids-related Complex 161 99.80 Very High Very High Very High
Diabetes Mellitus 51 99.50 Very High Very High Very High
Disease 24 95.04 Very High Very High Very High
Schizophrenia 166 94.96 High High
Gliosis 1 93.84 High High
Stress 110 92.56 High High
Cardiovascular Disease 32 89.72 High High
Anxiety Disorder 5 89.36 High High
Obesity 73 74.80 Quite High
INFLAMMATION 22 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Slow release of BPA or metabolites from tissue sites could theoretically lead to oxidative endothelial cell damage.
Localization (release) of BPA in endothelial cell
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.63 Pain Relevance 0.06
Higher BPA concentrations were also associated with diagnosed diabetes (OR per 1SD increase in BPA concentration?
Localization (concentration) of BPA associated with diabetes mellitus
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.48 Pain Relevance 0
The DST is a test of delayed feedback mechanisms in the HPA axis which may then lead to hypersecretion of cortisol.
Localization (hypersecretion) of DST
3) Confidence 0.32 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.24 Pain Relevance 0
Further, single cells were readily discriminated in both the DMH and Arc (Fig. 2A and 2C).
Localization (discriminated) of DMH associated with aids-related complex
4) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.45 Pain Relevance 0
Then other brain regions that might be targets for POMC mediated effects are discussed, namely the paraventricular nucleus (PVN), lateral hypothalamus, dorsomedial nucleus (DMH), supraoptic nucleus (SON), ventromedial nucleus (VMH), periventricular nucleus, nucleus accumbens and amygdala.
Localization (effects) of DMH in nucleus associated with nucleus accumbens and amygdala
5) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.06 Pain Relevance 0.33
All micro-dissected DMH (n = 13) and Arc complex (n = 10) cultures were rhythmic (Fig. 5C and 5D, Table 1).
Localization (dissected) of DMH associated with aids-related complex
6) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.64 Pain Relevance 0
Characterisation of CATS- and CATX-expressing cells
Localization (Characterisation) of CATX
7) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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