INT214144

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.94
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck, Pomc) extracellular region (Cck, Pomc) signal transduction (Pomc)
generation of precursor metabolites and energy (Pomc) DNA binding (Cck) cell-cell signaling (Pomc)
Anatomy Link Frequency
vagus nerve 1
Cck (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 81 100.00 Very High Very High Very High
Cholecystokinin 24 100.00 Very High Very High Very High
vagus nerve 21 99.12 Very High Very High Very High
Endogenous opioid 6 93.32 High High
antagonist 30 91.60 High High
Eae 3 64.20 Quite High
Central nervous system 45 59.92 Quite High
Neuropeptide 3 50.28 Quite High
Action potential 12 32.08 Quite Low
parabrachial 3 25.44 Quite Low
Disease Link Frequency Relevance Heat
Anorexia 42 99.84 Very High Very High Very High
Body Weight 9 84.24 Quite High
Obesity 171 70.40 Quite High
Sprains And Strains 15 56.20 Quite High
Appetite Loss 30 5.00 Very Low Very Low Very Low
Weight Gain 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
Hyperphagia 9 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POMC neurones in the NTS, expressing GFP, are activated both by cholecystokinin (CCK) and by satiety induced by feeding, as shown by immunocytochemical measurement of Fos protein [88].
CCK Positive_regulation (activated) of POMC associated with medulla and cholecystokinin
1) Confidence 0.15 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.38 Pain Relevance 0.77
POMC neurones in the NTS, expressing GFP, are activated both by cholecystokinin (CCK) and by satiety induced by feeding, as shown by immunocytochemical measurement of Fos protein [88].
cholecystokinin Positive_regulation (activated) of POMC associated with medulla and cholecystokinin
2) Confidence 0.15 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.38 Pain Relevance 0.77
The dorsal motor nucleus of the vagus nerve (DMX), lying next to the NTS, has the highest density of MC4R in the brain [90] and may mediate the anorexia due to activation of the NTS POMC neurones by CCK [88].
CCK Positive_regulation (activation) of POMC in vagus nerve associated with medulla, anorexia, cholecystokinin and vagus nerve
3) Confidence 0.13 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.18 Pain Relevance 0.85

General Comments

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