INT214155

Context Info Confidence 0.20 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0

extracellular space (Lep, Pomc) signal transduction (Lep, Pomc) extracellular region (Lep, Pomc) intracellular (Lep) cell-cell signaling (Pomc) cytoplasm (Pomc)

Anatomy Link Frequency CSF 2 Lep (Mus musculus) Pomc (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 4 40.88 agonist 10 39.16 Central nervous system 15 23.32 medulla 27 5.00 antagonist 10 5.00 Cholecystokinin 8 5.00 amygdala 8 5.00 gABA 8 5.00 vagus nerve 7 5.00 Nucleus accumbens 5 5.00

Disease Link Frequency Relevance Heat Obesity 57 94.04 Appetite Loss 10 72.16 Anorexia 14 10.52 Sprains And Strains 5 5.00 Weight Gain 4 5.00 Stress 4 5.00 Body Weight 3 5.00 Syndrome 3 5.00 Hyperphagia 3 5.00 Targeted Disruption 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It should be noted that as leptin regulates POMC synthesis and release, it is difficult to dissect the role of POMC turnover in the CSF [122]. ?

leptin Regulation (regulates) of Gene_expression (synthesis) of POMC in CSF

1) Confidence 0.20 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.40 Pain Relevance 0

General Comments

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