INT214348

Context Info Confidence 0.01 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.29 Pain Relevance 2.57

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1) cytoplasm (Ubqln1)

Anatomy Link Frequency neuronal 2 DA neurons 2 striatum 2 Ubqln1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 448 100.00 Nucleus accumbens 10 95.16 Ventral tegmentum 60 95.04 Hippocampus 12 88.76 imagery 10 88.08 Desipramine 12 81.68 medulla 4 75.12 Eae 4 72.28 Pyramidal cell 6 71.84 Locus ceruleus 46 68.44

Disease Link Frequency Relevance Heat Urological Neuroanatomy 6 94.24 Diabetes Mellitus 12 69.88 Targeted Disruption 4 64.64 Depression 46 32.08 Psychosis 4 14.16 Manic Depressive Disorder 6 5.00 Drug Dependence 4 5.00 Amphetamine Dependence 2 5.00 Cognitive Disorder 2 5.00 Decapitation 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Figure 3 shows the effect of LY294002 pretreatment on AMPH-induced DA release.

Regulation (effect) of Localization (release) of DA associated with dopamine

1) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.45

Here we show that pharmacological manipulation of the PI3K signaling pathway caused by hypoinsulinemic conditions or selective pharmacological inhibition/activation of PI3K dramatically regulates the ability of AMPH to evoke DAT-mediated DA release in the striatum, as determined by HSCA.

Regulation (regulates) of Localization (release) of DA in striatum associated with dopamine

2) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.29

It is difficult to dissociate changes in DA release from changes in DA neuronal activity.

Regulation (changes) of Localization (release) of DA in neuronal associated with dopamine

3) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.72

NE and DA neurons converge in the medial PFC where NE terminals regulate DA release in this brain region.

Regulation (regulate) of Localization (release) of DA in DA neurons associated with dopamine

4) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.22 Pain Relevance 1.12

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