INT214348

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.29
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
neuronal 2
DA neurons 2
striatum 2
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 448 100.00 Very High Very High Very High
Nucleus accumbens 10 95.16 Very High Very High Very High
Ventral tegmentum 60 95.04 Very High Very High Very High
Hippocampus 12 88.76 High High
imagery 10 88.08 High High
Desipramine 12 81.68 Quite High
medulla 4 75.12 Quite High
Eae 4 72.28 Quite High
Pyramidal cell 6 71.84 Quite High
Locus ceruleus 46 68.44 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 94.24 High High
Diabetes Mellitus 12 69.88 Quite High
Targeted Disruption 4 64.64 Quite High
Depression 46 32.08 Quite Low
Psychosis 4 14.16 Low Low
Manic Depressive Disorder 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Amphetamine Dependence 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3 shows the effect of LY294002 pretreatment on AMPH-induced DA release.
Regulation (effect) of Localization (release) of DA associated with dopamine
1) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.45
Here we show that pharmacological manipulation of the PI3K signaling pathway caused by hypoinsulinemic conditions or selective pharmacological inhibition/activation of PI3K dramatically regulates the ability of AMPH to evoke DAT-mediated DA release in the striatum, as determined by HSCA.
Regulation (regulates) of Localization (release) of DA in striatum associated with dopamine
2) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.29
It is difficult to dissociate changes in DA release from changes in DA neuronal activity.
Regulation (changes) of Localization (release) of DA in neuronal associated with dopamine
3) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0 Pain Relevance 0.72
NE and DA neurons converge in the medial PFC where NE terminals regulate DA release in this brain region.
Regulation (regulate) of Localization (release) of DA in DA neurons associated with dopamine
4) Confidence 0.00 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.22 Pain Relevance 1.12

General Comments

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