INT214355

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 3.72
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
myocyte 1
striatum 1
muscle fiber 1
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 33 99.48 Very High Very High Very High
Dopamine 447 99.44 Very High Very High Very High
cytokine 8 98.40 Very High Very High Very High
Paracetamol 180 96.00 Very High Very High Very High
Neurotransmitter 24 94.32 High High
dopamine receptor 20 83.64 Quite High
aspirin 1 83.44 Quite High
Nerve growth factor 34 80.96 Quite High
agonist 63 79.04 Quite High
antagonist 36 78.00 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 22 99.84 Very High Very High Very High
Apoptosis 53 98.92 Very High Very High Very High
Amphetamine Dependence 3 94.48 High High
Diabetes Mellitus 57 92.56 High High
Injury 20 86.20 High High
Stress 14 85.36 High High
Targeted Disruption 8 82.56 Quite High
Stroke 13 81.76 Quite High
Aging 114 79.36 Quite High
Disease 16 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During Western blot studies, subsequent Shh transfection of the respective siRNA transfected cells showed that PI3K/Akt abrogation failed to block Shh induced iNOS expression (Figure 3D; lane-3).
Akt Binding (abrogation) of
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
The phosphorylation of the GSK-3 fusion protein at Ser21/Ser9 by the immunoprecipitated Akt was detected by immunoblotting.
Akt Binding (immunoprecipitated) of
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.05 Pain Relevance 0
Akt dysfunction is associated with decreases of muscle fiber cross-sectional area
Akt Binding (associated) of in muscle fiber
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.07 Pain Relevance 0.39
Akt dysfunction is associated with increases in myocyte apoptosis
Akt Binding (associated) of in myocyte associated with apoptosis
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.18 Pain Relevance 0.37
We show that high glucose phosphorylates tuberin on Thr 1,462, a site known to be targeted by Akt.
Akt Binding (targeted) of
5) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.72 Pain Relevance 0
After the striatum is exposed to amphetamines, insulin signaling regulates dopamine via downstream phosphotidylinositol 3-kinase and protein kinase B targets.
protein kinase B Binding (targets) of in striatum associated with dopamine
6) Confidence 0.31 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0.17 Pain Relevance 0.20
To assess Akt activity in these studies, we measured its ability to phosphorylate in vitro GSK3?
Akt Binding (activity) of
7) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.09 Pain Relevance 0.09
Ultrasound-mediated disruption of the BBB is associated with increased phosphorylation of Akt and its downstream signaling molecule GSK3?
Akt Binding (associated) of
8) Confidence 0.30 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Akt is a downstream signaling molecule of tyrosine kinase receptors and is activated upon binding of these receptors to their cognate ligand molecules [40].
Akt Binding (binding) of
9) Confidence 0.28 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.35 Pain Relevance 0.12
As seen in Figure 1, STZ treatment reduces basal Akt activity, reflected by a decreased phosphorylation of GSK3?
Akt Binding (activity) of
10) Confidence 0.27 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.09 Pain Relevance 0.09
Akt interacts with and inhibits the Raf-MEK-MAPK pathway [46], but this interaction occurs only in certain stages of cell differentiation [47].
Akt Binding (interacts) of
11) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0.04
As such, Akt has been well recognized as an important regulator for multiple biological processes, including metabolism, cell size, apoptosis, and cell cycle progression [1].
Akt Binding (recognized) of associated with apoptosis
12) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.18 Pain Relevance 0.05
Immunofluorescent microscopy demonstrates that the elevated pAkt as well as pGSK3?
pAkt Binding (pGSK3) of
13) Confidence 0.26 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.10
Akt signaling exerts its neuroprotective role in cerebral ischemia animal models [18-20] via blocking of NF-?
Akt Binding (role) of associated with cv general 4 under development and ischemia
14) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2946287 Disease Relevance 1.21 Pain Relevance 0.36
Interestingly, dopamine has recently been shown to act through the Akt-GSK3?
Akt Binding (act) of associated with dopamine
15) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.43 Pain Relevance 0.28
We employed the same method here to determine if the Akt-GSK3?
Akt Spec (determine) Binding (determine) of
16) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.07 Pain Relevance 0.51

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