INT214358

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.25

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1) cytoplasm (Ubqln1)

Ubqln1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 103 100.00 Eae 2 84.96 imagery 5 64.72 Catecholamine 1 42.84 cocaine 4 5.00 Ventral tegmentum 3 5.00 midbrain 2 5.00 Neurotransmitter 2 5.00 addiction 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 6 82.56 Drug Dependence 2 5.00 Opiate Addiction 1 5.00 Apoptosis 1 5.00 Amphetamine Dependence 1 5.00 Congenital Anomalies 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Decapitation 1 5.00 Depression 1 5.00 Manic Depressive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, in light of these data, it is possible that the regulation of AMPH-induced DA efflux—promoted by insulin and PI3K signaling—is mediated by changes in DAT cell surface expression.

Positive_regulation (mediated) of Spec (possible) Regulation (regulation) of DA associated with dopamine

1) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.08 Pain Relevance 0.25

General Comments

This test has worked.