INT214362

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 1.58
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
plasma 8
brain 4
striatum 4
cortex 4
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 859 100.00 Very High Very High Very High
imagery 38 99.22 Very High Very High Very High
cocaine 25 95.16 Very High Very High Very High
monoamine 85 92.80 High High
Catecholamine 6 79.12 Quite High
depression 13 78.28 Quite High
Serotonin 29 71.20 Quite High
Eae 12 61.84 Quite High
tolerance 20 57.80 Quite High
positron emission tomography 7 56.64 Quite High
Disease Link Frequency Relevance Heat
Gliosis 35 98.76 Very High Very High Very High
Congenital Anomalies 34 91.44 High High
Cognitive Disorder 8 81.08 Quite High
Body Weight 49 80.04 Quite High
Psychosis 7 78.72 Quite High
Depression 13 78.28 Quite High
Anxiety Disorder 7 77.80 Quite High
Diabetes Mellitus 36 65.84 Quite High
Death 8 53.20 Quite High
Hyperglycemia 6 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively these data support the hypothesis that hypoinsulinemia, by downregulation of PI3K signaling (see Figure 3), significantly reduces AMPH-induced DA efflux because of reduced DAT plasma membrane expression.
Negative_regulation (reduced) of Gene_expression (expression) of DAT in plasma associated with dopamine
1) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.42
To evaluate whether the reduction in AMPH-induced DA efflux caused by hypoinsulinemic conditions is promoted by a decrease in DAT cell surface expression, we evaluated DAT levels at the plasma membrane in striatal synaptosomes from rats made hypoinsulinemic with STZ [13].
Spec (whether) Negative_regulation (decrease) of Gene_expression (expression) of DAT in plasma associated with dopamine
2) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21
The reduction in DA efflux determined by HSCA in the current studies may result either from a decreased DAT plasma membrane expression, as suggested by in vitro [11,13] and ex vivo [14,30] studies, from a diminished DA content [64], or from both.
Negative_regulation (decreased) of Gene_expression (expression) of DAT in plasma associated with dopamine
3) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.46
As shown in Figure 4, chronic depletion of insulin results in a significant (>40%) decrease in the level of biotinylated, membrane-associated DAT within synaptosomes, indicating that DAT cell surface expression was significantly reduced in hypoinsulinemic rats.
Negative_regulation (reduced) of Gene_expression (expression) of DAT
4) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.22
Of related interest, however, Schwendt at al. [42] have recently reported that extended (6 hours) access to METH self-administration caused persistent decreases in DAT protein expression in the prefrontal cortex and striatum without affecting DA and TH levels in these brain regions.
Negative_regulation (decreases) of Gene_expression (expression) of DAT protein in cortex associated with dopamine
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.09 Pain Relevance 0.12
Together, these findings suggest that METH can cause both neuroadaptative and neurotoxic changes in the mammalian brain depending on the intake, with lower doses of METH being able to induce transient alterations in markers of DA system integrity [40], [41] or neuroadaptive decreases in DAT protein expression without affecting DA and TH levels in the brain [42].
Negative_regulation (decreases) of Gene_expression (expression) of DAT protein in brain associated with dopamine
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.14 Pain Relevance 0.24
However, coexpression of the MG encoding the peptide DAT-CT583–620 significantly inhibited the increasing effects of DAT-mediated DA translocation by CPE.
Negative_regulation (inhibited) of Gene_expression (coexpression) of DAT-CT583 associated with dopamine
7) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.25
Collectively these data support the hypothesis that hypoinsulinemia, by downregulation of PI3K signaling (see Figure 3), significantly reduces AMPH-induced DA efflux because of reduced DAT plasma membrane expression.
Negative_regulation (reduces) of Gene_expression (expression) of DAT in plasma associated with dopamine
8) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.45
Because insulin and PI3K signaling have been shown to fine-tune DAT cell surface expression [13,29], it is possible that inhibition of PI3K signaling in vivo, by reducing DAT cell surface expression, inhibits AMPH-induced DA efflux and, hence, its behavioral effects.
Negative_regulation (reducing) of Gene_expression (expression) of DAT associated with dopamine
9) Confidence 0.26 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.41
Yet, they are in partial agreement with data of Schwendt et al. [42], who showed very recently that METH self-administration caused decreases in the expression of DAT protein in the striatum and cortex without affecting DA concentrations or TH protein levels.
Negative_regulation (decreases) of Gene_expression (expression) of DAT protein in striatum associated with dopamine
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.24 Pain Relevance 0.16
Our results are in agreement with findings from post-mortem studies that have reported decreased DA levels and reduced TH and DAT protein expression in the striata of human METH addicts [16]–[18].
Negative_regulation (reduced) of Gene_expression (expression) of DAT protein associated with dopamine
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.31 Pain Relevance 0.14
Specifically, clinical imaging studies have demonstrated significant reductions in the levels of dopamine transporters (DAT) [8], [11], [13] and reactive gliosis [14], [15] in the brains of METH abusers.
Negative_regulation (reductions) of Gene_expression (levels) of DAT in brains associated with dopamine, gliosis and imagery
12) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.41 Pain Relevance 0.29
Of related interest, however, Schwendt at al. [42] have recently reported that extended (6 hours) access to METH self-administration caused persistent decreases in DAT protein expression in the prefrontal cortex and striatum without affecting DA and TH levels in these brain regions.
Negative_regulation (decreases) of in striatum Gene_expression (expression) of DAT protein in cortex associated with dopamine
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.09 Pain Relevance 0.12
Yet, they are in partial agreement with data of Schwendt et al. [42], who showed very recently that METH self-administration caused decreases in the expression of DAT protein in the striatum and cortex without affecting DA concentrations or TH protein levels.
Negative_regulation (decreases) of in cortex Gene_expression (expression) of DAT protein in striatum associated with dopamine
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.24 Pain Relevance 0.16

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