INT214364

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 103 97.68 Very High Very High Very High
Glutamate 5 76.00 Quite High
agonist 7 68.08 Quite High
imagery 5 9.60 Low Low
cocaine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Ventral tegmentum 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 71.24 Quite High
Death 6 64.96 Quite High
Apoptosis 14 55.28 Quite High
Drug Dependence 2 5.00 Very Low Very Low Very Low
Amphetamine Dependence 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Paralysis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To verify whether inhibition of PI3K signaling induced by STZ treatment correlates with changes in AMPH-induced DA efflux, we used HSCA to measure the release and clearance kinetics of striatal DA in vivo [14,40].
Spec (whether) Positive_regulation (induced) of Spec (whether) Negative_regulation (inhibition) of PI3K associated with dopamine
1) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.18
P2Y13 receptors were coupled to the well characterized PI3K/Akt dependent pathway, described for growth factors of the insulin family [10], resulting in the stabilization of the GSK3 substrate ?
Positive_regulation (coupled) of Negative_regulation (pathway) of PI3K
2) Confidence 0.24 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.12 Pain Relevance 0.07

General Comments

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