INT214368

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pik3cb, Ubqln1) cytoplasm (Pik3cb, Ubqln1) cytosol (Pik3cb)
signal transduction (Pik3cb) endoplasmic reticulum (Ubqln1) cell adhesion (Pik3cb)
Pik3cb (Rattus norvegicus)
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 103 100.00 Very High Very High Very High
addiction 2 98.56 Very High Very High Very High
Opioid 1 98.12 Very High Very High Very High
tolerance 1 97.48 Very High Very High Very High
alcohol 1 97.08 Very High Very High Very High
cocaine 4 95.96 Very High Very High Very High
Neurotransmitter 2 77.60 Quite High
midbrain 2 70.60 Quite High
depression 1 57.24 Quite High
drug abuse 1 32.28 Quite Low
Disease Link Frequency Relevance Heat
Opiate Addiction 1 98.56 Very High Very High Very High
Apoptosis 1 90.88 High High
Manic Depressive Disorder 1 58.08 Quite High
Depression 1 57.24 Quite High
Attention Deficit Hyperactivity Disorder 1 56.76 Quite High
Drug Dependence 2 32.28 Quite Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Amphetamine Dependence 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism underlying the regulation of DA clearance by PI3K seems to rely on DAT trafficking, as Garcia et al. [13] and Wei et al. [29] recently demonstrated that Akt activity is critical for sustaining human DAT (hDAT) membrane expression and function.
PI3K Regulation (regulation) of DA associated with dopamine
1) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.36 Pain Relevance 0.68

General Comments

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