INT214369

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pik3cb, Akt1) cytosol (Pik3cb, Akt1) signal transduction (Pik3cb, Akt1)
nucleus (Pik3cb, Akt1) nucleoplasm (Akt1) transport (Akt1)
Pik3cb (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 96.16 Very High Very High Very High
Dopamine 206 89.28 High High
midbrain 4 89.16 High High
cocaine 8 76.48 Quite High
depression 2 75.80 Quite High
alcohol 2 74.24 Quite High
tolerance 2 73.60 Quite High
Opioid 2 72.08 Quite High
addiction 4 71.52 Quite High
drug abuse 2 50.84 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 86.80 High High
Manic Depressive Disorder 2 76.64 Quite High
Depression 2 75.80 Quite High
Attention Deficit Hyperactivity Disorder 2 75.32 Quite High
Opiate Addiction 2 72.08 Quite High
Drug Dependence 4 50.84 Quite High
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low
Amphetamine Dependence 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, RTKs are known to stimulate phosphotidylinositol 3-kinase (PI3K) signaling, which in turn activates protein kinase B (PKB), also known as Akt [23,24].
PI3K Positive_regulation (activates) of protein kinase B
1) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.44 Pain Relevance 0.71
Additionally, RTKs are known to stimulate phosphotidylinositol 3-kinase (PI3K) signaling, which in turn activates protein kinase B (PKB), also known as Akt [23,24].
PI3K Positive_regulation (activates) of PKB
2) Confidence 0.56 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.44 Pain Relevance 0.71

General Comments

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