INT214370

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) cytoskeleton (Amph) plasma membrane (Slc6a3)
cytoplasm (Amph) transmembrane transport (Slc6a3)
Anatomy Link Frequency
brain 1
Slc6a3 (Rattus norvegicus)
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 8 100.00 Very High Very High Very High
Dopamine 206 94.28 High High
midbrain 4 91.60 High High
depression 2 87.20 High High
Eae 4 86.40 High High
drug abuse 2 86.12 High High
Catecholamine 2 66.96 Quite High
Neurotransmitter 4 46.96 Quite Low
addiction 4 28.20 Quite Low
Opioid 2 27.76 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 12 90.40 High High
Attention Deficit Hyperactivity Disorder 2 89.12 High High
Depression 2 87.20 High High
Drug Dependence 4 86.12 High High
Manic Depressive Disorder 2 86.00 High High
Opiate Addiction 2 28.20 Quite Low
Apoptosis 2 20.52 Low Low
Amphetamine Dependence 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAT is a target of multiple psychomotor stimulants including cocaine, methamphetamine and amphetamine (AMPH) [6].
DAT Regulation (target) of AMPH associated with cocaine
1) Confidence 0.14 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.35 Pain Relevance 0.47
cells by STZ in rats is a model of insulin depletion, and as such, we hypothesized that PI3K signaling in the brain, as well as DAT cell surface expression and possibly DAT-mediated behavioral effects of AMPH, would be reduced following STZ pretreatment.
DAT-mediated Spec (possibly) Regulation (effects) of AMPH in brain
2) Confidence 0.13 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.09 Pain Relevance 0.35

General Comments

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