INT214389

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.88
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
20S (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 18 92.96 High High
tetrodotoxin 5 76.52 Quite High
tolerance 4 63.96 Quite High
Hippocampus 3 26.52 Quite Low
depression 2 17.68 Low Low
Glutamate receptor 8 11.44 Low Low
Central nervous system 29 5.00 Very Low Very Low Very Low
Neuropeptide 11 5.00 Very Low Very Low Very Low
projection neuron 10 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 95.36 Very High Very High Very High
Poisoning 1 88.80 High High
Neurodegenerative Disease 13 88.56 High High
Malaria 31 79.04 Quite High
Targeted Disruption 43 68.56 Quite High
Disease 52 66.48 Quite High
Multiple Sclerosis 87 60.56 Quite High
Aging 14 50.00 Quite Low
Depression 2 17.68 Low Low
Aids-related Complex 1 13.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ChymT-like and PGPH activities of the 20S proteasome were measured using the remaining piece of striatal tissue and were acutely elevated at 1 and 24 hr after a single ip dose of PQ in the STR (Figure 5A).
Gene_expression (proteasome) of 20S
1) Confidence 0.65 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.18 Pain Relevance 0.11
These recent studies also highlight the major shortcomings of earlier reports assessing proteasome function in brain homogenates utilizing enzymatic assays, which do not discriminate between 26S versus 20S proteasomes, and also cannot differentiate between various cell types.
Gene_expression (proteasomes) of 20S in brain
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0.36 Pain Relevance 0
To investigate the impact of the LMP2 R60H polymorphism on the production of the epitope MBP111–119, we performed in vitro digestions of the substrate MBP102–129 by 20S immunoproteasomes (with or without PA28-??)
Gene_expression (immunoproteasomes) of 20S
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.11 Pain Relevance 0.03
As expected, there was a shift from 26S proteasomes to 20S proteasomes 4?
Gene_expression (proteasomes) of 20S
4) Confidence 0.65 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.08
Ubiquinated proteins undergo proteolysis in a multi-subunit complex known as the 26S proteasome, which is comprised of a 20S core and 19S regulatory complexes.
Gene_expression (comprised) of 20S
5) Confidence 0.65 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.23 Pain Relevance 0

General Comments

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