INT214503

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 7.81
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (FADS3) oxidoreductase activity (FADS3) endoplasmic reticulum (FADS3)
molecular_function (FADS3)
Anatomy Link Frequency
fat 2
adipose tissue 2
extracellular matrix 1
FADS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 92.44 High High
Neuropeptide 1 73.76 Quite High
cytokine 6 68.44 Quite High
Inflammation 14 60.04 Quite High
agonist 3 38.88 Quite Low
Glutamate 6 38.24 Quite Low
antagonist 8 36.32 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 1143 99.80 Very High Very High Very High
Disease 117 98.96 Very High Very High Very High
Obesity 78 98.40 Very High Very High Very High
Neurodegenerative Disease 9 92.96 High High
Myocardial Infarction 14 83.28 Quite High
Coronary Heart Disease 12 81.76 Quite High
Coronary Artery Disease 18 81.68 Quite High
Disorder Of Lipid Metabolism 155 75.60 Quite High
Hyperlipidemia 46 74.84 Quite High
Stress 4 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings demonstrate that FADS3 expression is regulated by rs3737787 genotypes in adipose tissue, and that this differential expression causes increased risk for FCHL.
Gene_expression (expression) of FADS3 in adipose tissue associated with familial combined hyperlipidemia and obesity
1) Confidence 0.75 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.80 Pain Relevance 0
We then tested whether the two SNPs rs174547 and rs102275 predicted the expression of FADS1 and/or FADS3 in the Mexican FCHL case/control fat biopsies.
Gene_expression (expression) of FADS3 in fat associated with familial combined hyperlipidemia
2) Confidence 0.75 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.73 Pain Relevance 0
We followed-up a causal candidate gene for both FCHL and TGs, fatty acid desaturase 3 (FADS3), residing in the FADS1-2-3 locus, which was recently implicated for TGs in a meta-analysis of genome-wide association studies for lipids in Caucasians [38].
Gene_expression (residing) of FADS1-2-3 associated with familial combined hyperlipidemia
3) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.76 Pain Relevance 0
0.089), and little to no evidence for prediction of FADS3 expression (rs174547 correlation?
Gene_expression (expression) of FADS3
4) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.61 Pain Relevance 0
We followed-up a causal candidate gene for both FCHL and TGs, fatty acid desaturase 3 (FADS3), residing in the FADS1-2-3 locus, which was recently implicated for TGs in a meta-analysis of genome-wide association studies for lipids in Caucasians [38].
Gene_expression (residing) of FADS3 associated with familial combined hyperlipidemia
5) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.75 Pain Relevance 0
We followed-up a causal candidate gene for both FCHL and TGs, fatty acid desaturase 3 (FADS3), residing in the FADS1-2-3 locus, which was recently implicated for TGs in a meta-analysis of genome-wide association studies for lipids in Caucasians [38].
Gene_expression (residing) of fatty acid desaturase 3 associated with familial combined hyperlipidemia
6) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.76 Pain Relevance 0
We hypothesized that because FADS3 expression was associated with FCHL, any variation affecting the expression of FADS3 could be associated with FCHL or an FCHL component trait, especially TGs.
Gene_expression (expression) of FADS3 associated with familial combined hyperlipidemia
7) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.96 Pain Relevance 0
Of the three fatty acid desaturase genes in the FADS1-2-3 locus, we observed that only the expression of FADS3 was associated with FCHL disease status in adipose tissue (204257_at correlation?
Gene_expression (expression) of FADS3 in adipose tissue associated with familial combined hyperlipidemia, obesity and disease
8) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.83 Pain Relevance 0
We hypothesized that because FADS3 expression was associated with FCHL, any variation affecting the expression of FADS3 could be associated with FCHL or an FCHL component trait, especially TGs.
Gene_expression (expression) of FADS3 associated with familial combined hyperlipidemia
9) Confidence 0.59 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.98 Pain Relevance 0
Among the 1943 genes differentially expressed, genes down-regulated are involved in osteogenesis, chondrogenesis, adipogenesis, myogenesis and extracellular matrix component (tuftelin, AGC1, FADS3, tropomyosin, fibronectin, ECM2, HAPLN1, vimentin).
Gene_expression (expressed) of FADS3 in extracellular matrix
10) Confidence 0.13 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358905 Disease Relevance 0.22 Pain Relevance 0.08
As demonstrated by Kay et al. [86] approximately 90 % of 9c,11t-CLA in milk fat was produced endogenously involving delta-9-desaturation of VA.
Gene_expression (produced) of delta-9-desaturation in fat
11) Confidence 0.01 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2039733 Disease Relevance 0.41 Pain Relevance 0.09

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