INT214514

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 5.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SP110) nucleus (SP110) DNA binding (SP110)
signal transducer activity (SP110)
Anatomy Link Frequency
HL-60 7
SP110 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 10 28.44 Quite Low
Inflammatory response 10 20.16 Low Low
headache 10 13.08 Low Low
Disease Link Frequency Relevance Heat
Infection 300 99.36 Very High Very High Very High
Mycobacterial Infection 20 98.92 Very High Very High Very High
Rickettsiaceae Infection 10 93.60 High High
Disease 20 92.36 High High
Immunodeficiency 10 90.96 High High
Hepatitis C Virus Infection 10 89.88 High High
Influenza Virus Infection 10 83.64 Quite High
Vesicular Stomatitis 10 82.84 Quite High
Death 20 77.28 Quite High
Anaplasmosis 70 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, silencing of Sp110 expression reduced pathogen infection/multiplication, thus suggesting that A. phagocytophilum can modulate the transcription of Sp110 to facilitate infection of human HL-60 cells.
Gene_expression (expression) of Sp110 in HL-60 associated with infection
1) Confidence 0.77 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.46 Pain Relevance 0
The expression of Sp110 was silenced in HL-60 cells by RNAi using a combination of two different pre-designed siRNAs to Sp110 (siRNAs IDs 145432 and 241448) and to actin-related protein 3 (ARP3) (NM_020445; siRNAs IDs 127242 and 127243) and P-selectin glycoprotein ligand-1 (PSGL-1) (NM_003006; siRNAs IDs 12441 and 142575) as negative and positive controls, respectively (Ambion, Austin, TX, USA).
Gene_expression (expression) of Sp110 in HL-60
2) Confidence 0.77 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.13 Pain Relevance 0
In summary, we have shown that A. phagocytophilum increases Sp110 mRNA levels in infected human promyelocytic HL-60 cells.
Gene_expression (levels) of Sp110 mRNA in HL-60
3) Confidence 0.67 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.43 Pain Relevance 0
To test these hypotheses, the effect of Sp110 silencing by RNAi was evaluated on A. phagocytophilum infection of HL-60 cells.
Gene_expression (silencing) of Sp110 in HL-60 associated with infection
4) Confidence 0.67 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.28 Pain Relevance 0
The effect of Sp110 expression on A. phagocytophilum infection was determined by RNA interference (RNAi).
Gene_expression (expression) of Sp110 associated with infection
5) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.71 Pain Relevance 0
As in mice, Ipr1-like expression was higher in European wild boar resistant to natural M. bovis infection [12].
Gene_expression (expression) of Ipr1-like associated with infection
6) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.97 Pain Relevance 0
While Sp110 mRNA levels increased concurrently with A. phagocytophilum infections in HL-60 cells, the silencing of Sp110 expression by RNA interference resulted in decreased infection levels.


Gene_expression (expression) of Sp110 in HL-60 associated with infection
7) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.78 Pain Relevance 0
These results demonstrated that Sp110 expression is required for A. phagocytophilum infection and multiplication in HL-60 cells, and suggest a previously undescribed mechanism by which A. phagocytophilum modulates Sp110 mRNA levels to facilitate establishment of infection of human HL-60 cells.



Gene_expression (expression) of Sp110 in HL-60 associated with infection
8) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.75 Pain Relevance 0
The expression of Sp110 was silenced in HL-60 cells by RNAi using pre-designed siRNAs using the Nucleofector 96-well shuttle system (Amaxa Biosystems, Gaithersburg, MD, USA).
Gene_expression (expression) of Sp110 in HL-60
9) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.77 Pain Relevance 0
Furthermore, the expression of Sp110 and PSGL-1 were shown to be silenced by 85 ± 9% and 61 ± 18% (P < 0.05; N = 8), respectively when compared to ARP3 siRNA-nucleofected controls.
Gene_expression (expression) of Sp110
10) Confidence 0.60 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.37 Pain Relevance 0

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