INT214516

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SP110) nucleus (SP110) DNA binding (SP110)
signal transducer activity (SP110)
Anatomy Link Frequency
HL-60 3
SP110 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 180 99.52 Very High Very High Very High
Anaplasmosis 42 90.68 High High
Rickettsiaceae Infection 6 40.80 Quite Low
Fever 18 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low
Mycobacterial Infection 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 6 5.00 Very Low Very Low Very Low
Myalgia 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sp110 and PSGL-1 mRNA levels were determined after RNAi by real-time RT-PCR, normalized against human ?
Transcription (levels) of Sp110
1) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.16 Pain Relevance 0
Furthermore, silencing of Sp110 expression reduced pathogen infection/multiplication, thus suggesting that A. phagocytophilum can modulate the transcription of Sp110 to facilitate infection of human HL-60 cells.
Transcription (transcription) of Sp110 in HL-60 associated with infection
2) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.46 Pain Relevance 0
The mechanism by which A. phagocytophilum modulates the transcription of Sp110 to enhance infection of human HL-60 cells will require further study.


Transcription (transcription) of Sp110 in HL-60 associated with infection
3) Confidence 0.72 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.40 Pain Relevance 0
Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells

Background

Transcription (transcription) of Sp110 associated with infection
4) Confidence 0.53 Published 2007 Journal BMC Infect Dis Section Title Doc Link PMC2039740 Disease Relevance 0.54 Pain Relevance 0
As shown here for A. phagocytophilum, Sp110 transcription is induced by some DNA viruses, suggesting that this mechanism may represent an evolutionary adaptation that facilitates pathogen replication [18].


Transcription (transcription) of Sp110
5) Confidence 0.53 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.36 Pain Relevance 0
The human Sp110 and A. phagocytophilum msp4 mRNA levels were evaluated by real-time RT-PCR in infected human HL-60 cells sampled at 0, 12, 24, 48, 72 and 96 hours post-infection.
Transcription (levels) of Sp110 in HL-60 associated with infection
6) Confidence 0.46 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.58 Pain Relevance 0

General Comments

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