INT214529

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 90.64 High High
psoriasis 50 50.00 Quite Low
cytokine 19 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crohn's Disease 8 98.68 Very High Very High Very High
INFLAMMATION 14 90.64 High High
Skin Diseases 5 89.60 High High
Systemic Lupus Erythematosus 7 77.44 Quite High
Psoriasis 69 50.00 Quite Low
Disease 49 50.00 Quite Low
Wegener's Granulomatosis 1 30.24 Quite Low
Microscopic Polyangiitis 1 29.12 Quite Low
Autoimmune Disease 1 26.32 Quite Low
Manic Depressive Disorder 1 24.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The detection limits for these assays were 0.05 and 0.1 ng/ml respectively, using synthetic hBD-2 and hBD-3 for calibration.


Negative_regulation (using) of hBD-2
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.18 Pain Relevance 0.05
Another report has detected variability in copy number of the beta defensin 2 gene (DEFB4) on Chromosome 8p23.1 in Crohn disease [71].
Negative_regulation (number) of beta defensin 2 gene associated with crohn's disease
2) Confidence 0.34 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.

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