INT214557

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
B-cells 2
lymphocytes 2
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 64 98.20 Very High Very High Very High
cytokine 4 50.72 Quite High
methotrexate 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
anti-cytokine treatment 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 67 98.20 Very High Very High Very High
Hodgkin's Disease 26 97.84 Very High Very High Very High
Systemic Lupus Erythematosus 66 96.28 Very High Very High Very High
Lymphatic System Cancer 123 84.72 Quite High
Apoptosis 6 77.12 Quite High
Diffuse Large B-cell Lymphoma 56 70.16 Quite High
Bacterial Infection 17 69.92 Quite High
B-cell Lymphoma 27 67.52 Quite High
Disease 59 63.20 Quite High
Cancer 43 62.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacodynamic properties of rituximab are related to its specificity for the CD20 membrane protein, found on the surface of B-cells.
Regulation (related) of CD20 Binding (specificity) of in B-cells
1) Confidence 0.37 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.52 Pain Relevance 0.19
Peripheral blood CD19+ lymphocytes were gated and stained for expression of CD27 in combination with CD20.
Regulation (gated) of CD20 Binding (combination) of in lymphocytes
2) Confidence 0.14 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.63 Pain Relevance 0
Galectin-1 (Gal1) is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in HRS cells and its expression affects the microenvironment in HL.
Regulation (regulated) of protein Binding (binding) of associated with hodgkin's disease
3) Confidence 0.05 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.10 Pain Relevance 0.03

General Comments

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