INT214566

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 13.39
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD27)
Anatomy Link Frequency
PCs 1
B cells 1
CD27 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 14 90.92 High High
Inflammation 28 68.36 Quite High
Arthritis 14 5.00 Very Low Very Low Very Low
abdominal pain 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 882 99.70 Very High Very High Very High
Infection 56 99.28 Very High Very High Very High
Disease 378 98.86 Very High Very High Very High
Autoimmune Disease 56 97.16 Very High Very High Very High
Opportunistic Infections 14 92.16 High High
Syndrome 28 88.56 High High
Systemic Sclerosis 14 87.52 High High
Bacterial Infection 238 86.64 High High
Congenital Anomalies 42 85.96 High High
Necrosis 14 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SLE patients, we found disturbances of peripheral B-cell homeostasis with accumulation of IgD+ CD38++ transitional B cells and CD27++ PCs.
Positive_regulation (accumulation) of CD27 in B cells associated with systemic lupus erythematosus
1) Confidence 0.68 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.58 Pain Relevance 0.08
Therefore, in case CD27 is chosen as a biomarker for monitoring SLE-disease activity, infections should be considered as a possible cause of CD27++ PC increase.
Spec (possible) Positive_regulation (cause) of CD27 associated with disease, systemic lupus erythematosus and infection
2) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.47 Pain Relevance 0.03
Patients with systemic lupus erythematosus (SLE) exhibit an expanded population of CD27++ PCs, while the number of CD27?
Positive_regulation (population) of CD27 associated with systemic lupus erythematosus
3) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.77 Pain Relevance 0
Within the group of CTD-suspected patients, patients with serum ANAs had similar frequencies of CD27?
Positive_regulation (frequencies) of CD27 associated with disease
4) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.38 Pain Relevance 0
In contrast to our data, in the prior study, anti-SS-A/B and anti-dsDNA antibodies were found to be associated with increased CD27++ PC frequencies (25).
Positive_regulation (increased) of CD27
5) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.98 Pain Relevance 0
The frequency of CD27++ PCs has been shown to significantly correlate with SLE-disease activity: patients with active SLE had higher frequencies of PCs than patients with inactive SLE (12, 25).
Positive_regulation (frequency) of CD27 associated with disease and systemic lupus erythematosus
6) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.71 Pain Relevance 0
It is unknown whether the presence of serum ANAs coincide with elevated frequencies of CD27++ PCs.
Spec (whether) Positive_regulation (frequencies) of CD27
7) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.63 Pain Relevance 0
Insights into the behavior of the PC compartment are essential to validate CD27 as a reliable biomarker for SLE.
Positive_regulation (validate) of CD27 associated with systemic lupus erythematosus
8) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.49 Pain Relevance 0
In support, others described that patients with inactive SLE had increased frequencies of CD27++ PCs but normal absolute numbers of PCs, whereas patients with active SLE had elevated frequencies and absolute numbers of PCs (12, 14).
Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus
9) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.97 Pain Relevance 0.06
These patients had significantly lower frequencies of CD27++ PCs compared with SLE patients suggesting a possible diagnostic value of PC analyses in SLE.
Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus
10) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.10 Pain Relevance 0
SLE patients showed increased frequencies of CD27++/CD20?
Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus
11) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.48 Pain Relevance 0
These findings may indicate that autoantibody production is not preceded by accumulation of CD27++ PCs.
Positive_regulation (accumulation) of CD27
12) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.97 Pain Relevance 0
Within the group of SLE patients, the presence of serum anti-RNP antibodies (N = 13) was found to be associated with a higher frequency of CD27++/CD20?
Positive_regulation (frequency) of CD27 associated with systemic lupus erythematosus
13) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.30 Pain Relevance 0
Peripheral blood B lymphocytes with high levels of CD27 (CD27++) were characterized as PCs, which express low levels of CD19 and surface Ig, high amounts of CD38 and CD138, and are CD20?
Positive_regulation (levels) of CD27 in PCs
14) Confidence 0.46 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.56 Pain Relevance 0

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