INT214566

Context Info Confidence 0.68 First Reported 2007 Last Reported 2007 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 14 Disease Relevance 13.39 Pain Relevance 0.17

extracellular region (CD27)

Anatomy Link Frequency PCs 1 B cells 1 CD27 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 14 90.92 Inflammation 28 68.36 Arthritis 14 5.00 abdominal pain 14 5.00

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 882 99.70 Infection 56 99.28 Disease 378 98.86 Autoimmune Disease 56 97.16 Opportunistic Infections 14 92.16 Syndrome 28 88.56 Systemic Sclerosis 14 87.52 Bacterial Infection 238 86.64 Congenital Anomalies 42 85.96 Necrosis 14 78.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In SLE patients, we found disturbances of peripheral B-cell homeostasis with accumulation of IgD+ CD38++ transitional B cells and CD27++ PCs.

Positive_regulation (accumulation) of CD27 in B cells associated with systemic lupus erythematosus

1) Confidence 0.68 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.58 Pain Relevance 0.08

Therefore, in case CD27 is chosen as a biomarker for monitoring SLE-disease activity, infections should be considered as a possible cause of CD27++ PC increase.

Spec (possible) Positive_regulation (cause) of CD27 associated with disease, systemic lupus erythematosus and infection

2) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.47 Pain Relevance 0.03

Patients with systemic lupus erythematosus (SLE) exhibit an expanded population of CD27++ PCs, while the number of CD27?

Positive_regulation (population) of CD27 associated with systemic lupus erythematosus

3) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.77 Pain Relevance 0

Within the group of CTD-suspected patients, patients with serum ANAs had similar frequencies of CD27?

Positive_regulation (frequencies) of CD27 associated with disease

4) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.38 Pain Relevance 0

In contrast to our data, in the prior study, anti-SS-A/B and anti-dsDNA antibodies were found to be associated with increased CD27++ PC frequencies (25).

Positive_regulation (increased) of CD27

5) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.98 Pain Relevance 0

The frequency of CD27++ PCs has been shown to significantly correlate with SLE-disease activity: patients with active SLE had higher frequencies of PCs than patients with inactive SLE (12, 25).

Positive_regulation (frequency) of CD27 associated with disease and systemic lupus erythematosus

6) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.71 Pain Relevance 0

It is unknown whether the presence of serum ANAs coincide with elevated frequencies of CD27++ PCs.

Spec (whether) Positive_regulation (frequencies) of CD27

7) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.63 Pain Relevance 0

Insights into the behavior of the PC compartment are essential to validate CD27 as a reliable biomarker for SLE.

Positive_regulation (validate) of CD27 associated with systemic lupus erythematosus

8) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.49 Pain Relevance 0

In support, others described that patients with inactive SLE had increased frequencies of CD27++ PCs but normal absolute numbers of PCs, whereas patients with active SLE had elevated frequencies and absolute numbers of PCs (12, 14).

Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus

9) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.97 Pain Relevance 0.06

These patients had significantly lower frequencies of CD27++ PCs compared with SLE patients suggesting a possible diagnostic value of PC analyses in SLE.

Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus

10) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.10 Pain Relevance 0

SLE patients showed increased frequencies of CD27++/CD20?

Positive_regulation (frequencies) of CD27 associated with systemic lupus erythematosus

11) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.48 Pain Relevance 0

These findings may indicate that autoantibody production is not preceded by accumulation of CD27++ PCs.

Positive_regulation (accumulation) of CD27

12) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.97 Pain Relevance 0

Within the group of SLE patients, the presence of serum anti-RNP antibodies (N = 13) was found to be associated with a higher frequency of CD27++/CD20?

Positive_regulation (frequency) of CD27 associated with systemic lupus erythematosus

13) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.30 Pain Relevance 0

Peripheral blood B lymphocytes with high levels of CD27 (CD27++) were characterized as PCs, which express low levels of CD19 and surface Ig, high amounts of CD38 and CD138, and are CD20?

Positive_regulation (levels) of CD27 in PCs

14) Confidence 0.46 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.56 Pain Relevance 0

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