INT214569

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD27)
Anatomy Link Frequency
B cells 4
CD27 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 40 99.78 Very High Very High Very High
Inflammation 29 61.16 Quite High
Central nervous system 13 60.64 Quite High
imagery 19 20.60 Low Low
metalloproteinase 26 16.32 Low Low
chemokine 4 11.44 Low Low
intrathecal 14 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Shingles 3 5.00 Very Low Very Low Very Low
Dermatone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 45 99.78 Very High Very High Very High
Systemic Lupus Erythematosus 65 98.52 Very High Very High Very High
Disease 52 96.64 Very High Very High Very High
Congenital Anomalies 3 93.52 High High
Infection 47 88.32 High High
Neurological Disease 16 79.96 Quite High
Hypersensitivity 4 70.28 Quite High
Exanthema 19 68.68 Quite High
Herpes Zoster 102 64.72 Quite High
INFLAMMATION 25 61.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the presence of serum ANAs itself does not coincide with increased numbers of IgD+ CD38++ transitional B cells and CD27++ PCs as characteristically seen in SLE patients.
Positive_regulation (increased) of Localization (numbers) of CD27 in B cells associated with systemic lupus erythematosus
1) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.10 Pain Relevance 0
Additional stainings, which were however only possible in a few MS patients (due to limited CSF amounts), indicated that the majority of CSF B cells belong to the CD19+CD27+ memory B cell subset, while only a minority are naïve CD19+CD27?
Positive_regulation (due) of Localization (subset) of CD27 in B cells associated with multiple sclerosis
2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.78 Pain Relevance 0.19
Analysis of BAL samples revealed an increased frequency of proliferating CD27+IgD?
Positive_regulation (increased) of Localization (frequency) of CD27
3) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.28 Pain Relevance 0

General Comments

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