INT214571

Context Info Confidence 0.49 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 8 Disease Relevance 7.77 Pain Relevance 0

extracellular region (CD27)

Anatomy Link Frequency B-cell 2 CD27 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 8 43.28 Inflammation 16 20.72 Arthritis 8 5.00 abdominal pain 8 5.00

Disease Link Frequency Relevance Heat Disease 216 100.00 Systemic Lupus Erythematosus 504 99.72 Infection 32 99.30 Autoimmune Disease 32 95.72 Bacterial Infection 136 93.76 Syndrome 16 91.12 Systemic Sclerosis 8 90.08 Opportunistic Infections 8 83.96 Congenital Anomalies 24 67.76 Necrosis 8 62.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Within the group of SLE patients, the presence of serum anti-RNP antibodies (N = 13) was found to be associated with a higher frequency of CD27++/CD20?

Positive_regulation (frequency) of Gene_expression (/) of CD27 associated with systemic lupus erythematosus

1) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.30 Pain Relevance 0

Increased mean frequencies of CD27++/CD20?

Positive_regulation (Increased) of Gene_expression (frequencies) of CD27

2) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.68 Pain Relevance 0

SLE patients showed increased frequencies of CD27++/CD20?

Positive_regulation (frequencies) of Gene_expression (/) of CD27 associated with systemic lupus erythematosus

3) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.48 Pain Relevance 0

In support, we found that two newly diagnosed SLE patients admitted to our hospital due to an elevated disease activity had strongly elevated CD27++ PC numbers that persisted during their hospital stay.

Positive_regulation (elevated) of Gene_expression (numbers) of CD27 associated with disease and systemic lupus erythematosus

4) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.46 Pain Relevance 0

On admission (day 0), both SLE patients had elevated frequencies and absolute numbers of CD27++/CD20?

Positive_regulation (elevated) of Gene_expression (frequencies) of CD27 associated with systemic lupus erythematosus

5) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.93 Pain Relevance 0

Indeed, polyclonal B-cell activation due to infection could be considered as a possible cause of CD27++ PC expansion.

Spec (possible) Positive_regulation (cause) of Gene_expression (expansion) of CD27 in B-cell associated with infection

6) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.51 Pain Relevance 0

In support, we found that two newly diagnosed SLE patients admitted to our hospital due to an elevated disease activity had strongly elevated CD27++ PC numbers that persisted during their hospital stay.

Positive_regulation (elevated) of Gene_expression (numbers) of CD27 associated with disease and systemic lupus erythematosus

7) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.48 Pain Relevance 0

Patients with systemic lupus erythematosus (SLE) exhibit an expanded population of CD27++ PCs, while the number of CD27?

Positive_regulation (number) of Gene_expression (number) of CD27 associated with systemic lupus erythematosus

8) Confidence 0.49 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.93 Pain Relevance 0

General Comments

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