INT214574

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.24
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (SDC1) small molecule metabolic process (SDC1) extracellular region (SDC1)
plasma membrane (SDC1) protein complex (SDC1) lipid metabolic process (SDC1)
Anatomy Link Frequency
PCs 2
mature B cells 2
SDC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 52 97.40 Very High Very High Very High
Multiple sclerosis 80 94.80 High High
Inflammation 56 90.56 High High
imagery 48 88.56 High High
Inflammatory response 4 85.76 High High
intrathecal 28 82.24 Quite High
Spinal cord 14 70.36 Quite High
epidural 1 68.88 Quite High
chemokine 7 65.72 Quite High
Central nervous system 27 47.20 Quite Low
Disease Link Frequency Relevance Heat
Neurological Disease 32 98.24 Very High Very High Very High
Necrosis 2 97.84 Very High Very High Very High
Demyelinating Disease 90 94.80 High High
Hyperplasia 2 92.80 High High
Syndrome 13 92.24 High High
Disease 74 91.04 High High
Encephalitis 12 91.04 High High
Autoimmune Disease 4 88.56 High High
INFLAMMATION 48 87.52 High High
Hypoalbuminemia 1 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found a statistically significant accumulation of CSF mature B cells (CD19+CD138?)
Positive_regulation (accumulation) of CD138 in mature B cells
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2438478 Disease Relevance 1.02 Pain Relevance 0.55
We report a statistically significant increase of CSF mature B cells (CD19+CD138?)
Positive_regulation (increase) of CD138 in mature B cells
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.72 Pain Relevance 0.58
The cells stained positive for CD138 and CD79a, thus confirming plasma cell lineage.
Positive_regulation (positive) of CD138 in plasma cell
3) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923176 Disease Relevance 0.96 Pain Relevance 0.15
Peripheral blood B lymphocytes with high levels of CD27 (CD27++) were characterized as PCs, which express low levels of CD19 and surface Ig, high amounts of CD38 and CD138, and are CD20?
Positive_regulation (amounts) of CD138 in PCs
4) Confidence 0.14 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.54 Pain Relevance 0

General Comments

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