INT214575

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD38) hydrolase activity, acting on glycosyl bonds (CD38) plasma membrane (CD38)
nucleus (CD38)
Anatomy Link Frequency
B cells 2
HL-60 1
CD38 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 71.44 Quite High
chemokine 2 11.04 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphopenia 1 97.60 Very High Very High Very High
Systemic Lupus Erythematosus 63 97.24 Very High Very High Very High
Infection 72 96.80 Very High Very High Very High
Malaria 163 96.58 Very High Very High Very High
Disease 38 96.24 Very High Very High Very High
Congenital Anomalies 3 93.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 78.68 Quite High
Targeted Disruption 4 72.92 Quite High
Opportunistic Infections 1 51.72 Quite High
Bacterial Infection 17 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on functional experiments with neutrophil-like HL-60 cells, another interpretation is provided by our lab: cADPr could support intracellular Ca2+ release by regulating extracellular Ca2+ entry through non-SOCE [85].
Localization (release) of cADPr in HL-60
1) Confidence 0.34 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.07 Pain Relevance 0.04
Thus, the presence of serum ANAs itself does not coincide with increased numbers of IgD+ CD38++ transitional B cells and CD27++ PCs as characteristically seen in SLE patients.
Localization (numbers) of CD38 in B cells associated with systemic lupus erythematosus
2) Confidence 0.32 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.09 Pain Relevance 0
During acute malaria infections, there is an overall decrease in total CD19+ peripheral B-cell populations, yet further delineation of B-cell subsets demonstrates a transient increase in the proportion of CD38+ IgD-memory B cells (41,42).
Localization (proportion) of CD38 in B-cell associated with malaria and infection
3) Confidence 0.30 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 1.15 Pain Relevance 0

General Comments

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