INT214577

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PCS (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1 100.00 Very High Very High Very High
Lasting pain 59 99.86 Very High Very High Very High
rheumatoid arthritis 18 99.20 Very High Very High Very High
Chronic low back pain 1 90.20 High High
Cancer pain 1 83.48 Quite High
backache 1 79.76 Quite High
alcohol 16 78.88 Quite High
Inflammation 6 78.20 Quite High
Adalimumab 8 77.92 Quite High
Infliximab 9 73.92 Quite High
Disease Link Frequency Relevance Heat
Pain 89 99.86 Very High Very High Very High
Rheumatoid Arthritis 18 99.20 Very High Very High Very High
Cancer 5 97.24 Very High Very High Very High
Systemic Lupus Erythematosus 63 90.72 High High
Low Back Pain 7 90.20 High High
Cancer Pain 1 83.48 Quite High
Bacterial Infection 17 82.40 Quite High
INFLAMMATION 7 78.20 Quite High
Sepsis 1 56.64 Quite High
Aggression 2 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent experiments have established a key role for chemokines and their receptors expressed on PCs in guiding the release of PCs from secondary lymphoid organs and migration to their final destination (34, 35).
Positive_regulation (role) of Gene_expression (expressed) of PCs associated with chemokine
1) Confidence 0.29 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.53 Pain Relevance 0.12
In fact, LTRs with chronic pain had a lower PCS score than patients with rheumatoid arthritis (PCS = 39.60, P < .001) and cancer (PCS = 40.76, P ? 
Positive_regulation (lower) of Gene_expression (score) of PCS associated with cancer, lasting pain and rheumatoid arthritis
2) Confidence 0.09 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977061 Disease Relevance 1.46 Pain Relevance 1.30
For the change in the SF-36 PCS, the univariate analyses suggested that for each year increase in the patient's age, there was a lower improvement in the SF-36 PCS values (?
Positive_regulation (increase) of Gene_expression (values) of PCS
3) Confidence 0.04 Published 2010 Journal Arthritis Care & Research Section Body Doc Link PMC2909400 Disease Relevance 0.08 Pain Relevance 0.15
The top two PCs explain a modest proportion of the overall variance: 0.0027 for PC1 and 0.0022 for PC2, representing an excess of 0.0015 for PC1 and 0.0011 for PC2 above what would be expected by chance (Tracy-Widom P-values<10?
Positive_regulation (proportion) of Gene_expression (explain) of PCs
4) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2684636 Disease Relevance 0 Pain Relevance 0

General Comments

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