INT21463

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.44
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Epha1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 20 100.00 Very High Very High Very High
intrathecal 3 100.00 Very High Very High Very High
adenocard 37 99.98 Very High Very High Very High
Pain 1 97.48 Very High Very High Very High
Inflammation 1 96.60 Very High Very High Very High
opiate 3 96.48 Very High Very High Very High
Neuropathic pain 3 94.32 High High
Acute pain 1 94.20 High High
antagonist 12 93.60 High High
Antinociceptive 1 92.20 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 7 98.88 Very High Very High Very High
Pain 2 97.48 Very High Very High Very High
Injury 1 97.28 Very High Very High Very High
INFLAMMATION 1 96.60 Very High Very High Very High
Neuropathic Pain 4 94.32 High High
Nociception 2 92.96 High High
Cv Unclassified Under Development 3 91.12 High High
Nervous System Injury 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding and functional results are consistent with a model in which the enhancers bind preferentially to the agonist conformation of the A1 receptor, thereby shifting the receptor equilibrium in favor of agonist binding.
A1 receptor Binding (bind) of associated with agonist
1) Confidence 0.46 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2174510 Disease Relevance 0.09 Pain Relevance 0.61
Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.
A1 receptor Binding (binding) of associated with adenocard
2) Confidence 0.40 Published 1990 Journal Mol. Pharmacol. Section Title Doc Link 2174510 Disease Relevance 0 Pain Relevance 0.60
The enhancement was also specific for the A1 receptor, because agonist binding to A2 adenosine, M2 muscarinic, alpha 2 adrenergic, and delta opiate receptors showed little or no enhancement.
A1 receptor Binding (specific) of associated with adenocard, agonist and opiate
3) Confidence 0.35 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2174510 Disease Relevance 0 Pain Relevance 0.58
Allosteric adenosine modulators facilitate adenosine agonist binding to the A1 receptor.
A1 receptor Binding (binding) of associated with adenocard and agonist
4) Confidence 0.23 Published 2002 Journal Pain Section Abstract Doc Link 12031785 Disease Relevance 0.92 Pain Relevance 1.00
T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophen) is an allosteric adenosine receptor modulator that enhances adenosine binding to the A1 receptor.
A1 receptor Binding (binding) of associated with adenocard and intrathecal
5) Confidence 0.14 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15114225 Disease Relevance 0.44 Pain Relevance 0.46

General Comments

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