INT214649

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 6.06
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp1) mitosis (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
liver 6
plasma 2
intestines 2
Fabp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 286 85.84 High High
ischemia 182 82.28 Quite High
Inflammatory response 78 78.80 Quite High
anesthesia 65 78.40 Quite High
cytokine 13 68.84 Quite High
Inflammatory stimuli 13 63.12 Quite High
isoflurane 13 10.40 Low Low
Disease Link Frequency Relevance Heat
Injury 403 99.76 Very High Very High Very High
Liver Failure 65 94.12 High High
INFLAMMATION 377 85.84 High High
Cv Unclassified Under Development 182 82.28 Quite High
Cirrhosis 13 47.76 Quite Low
Death 39 19.52 Low Low
Reperfusion Injury 13 17.32 Low Low
Hepatotoxicity 13 11.40 Low Low
Metastasis 13 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some intestinal L-FABP release could have been expected when L-FABP, which is also expressed by the intestines, would have been released from injured enterocytes, but the absence of intestinal L-FABP release clearly indicates that organ manipulation during liver resection results in hepatocellular injury without causing intestinal injury.
Localization (release) of L-FABP in liver associated with injury
1) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.81 Pain Relevance 0.29
L-FABP was specifically released from the liver (p < 0.0001 vs. zero) and removed from circulation by the kidneys (p < 0.0001 vs. zero)


Localization (released) of L-FABP in liver
2) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.12 Pain Relevance 0.03
The data show that L-FABP was specifically released from the liver and not from the intestines.
Neg (not) Localization (released) of L-FABP in intestines
3) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.27 Pain Relevance 0.07
Some intestinal L-FABP release could have been expected when L-FABP, which is also expressed by the intestines, would have been released from injured enterocytes, but the absence of intestinal L-FABP release clearly indicates that organ manipulation during liver resection results in hepatocellular injury without causing intestinal injury.
Localization (release) of L-FABP in intestines associated with injury
4) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.63 Pain Relevance 0.19
By measuring concentration gradients across the intestines and the liver, we were able to show that the increased L-FABP levels during liver manipulation are exclusively due to L-FABP release from the liver.
Localization (release) of L-FABP in liver
5) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.59 Pain Relevance 0.19
L-FABP plasma concentrations were measured as described below and arteriovenous concentration differences were calculated to study the contribution of the intestines and the liver to systemic L-FABP release and to study renal clearance of L-FABP.
Localization (release) of L-FABP in plasma
6) Confidence 0.44 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.25 Pain Relevance 0.27
By measuring concentration gradients across the intestines and the liver, we were able to show that the increased L-FABP levels during liver manipulation are exclusively due to L-FABP release from the liver.
Localization (release) of L-FABP in liver
7) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.60 Pain Relevance 0.19
L-FABP plasma concentrations were measured as described below and arteriovenous concentration differences were calculated to study the contribution of the intestines and the liver to systemic L-FABP release and to study renal clearance of L-FABP.
Localization (clearance) of L-FABP in plasma
8) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.24 Pain Relevance 0.28
Fig. 4Fractional renal clearance of L-FABP in patients undergoing liver resection (n = 10).
Localization (clearance) of L-FABP in liver
9) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.20 Pain Relevance 0.10
No changes in L-FABP concentration were observed

Organ-specific FABP release

Localization (concentration) of L-FABP
10) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.36 Pain Relevance 0.11
Renal clearance of L-FABP correlated directly with their respective arterial concentrations (Fig. 4), resulting in a fractional extraction rate (arteriovenous gradient/arterial concentration × 100%) [11] of approximately 30%.
Localization (clearance) of L-FABP
11) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.05 Pain Relevance 0
Our study shows that the late postoperative peak of AST is more likely to be a reflection of slow leakage than of ongoing injury, since the leakage of small-molecular proteins L-FABP and GST?
Localization (leakage) of L-FABP associated with injury
12) Confidence 0.41 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 1.12 Pain Relevance 0.19
Some intestinal L-FABP release could have been expected when L-FABP, which is also expressed by the intestines, would have been released from injured enterocytes, but the absence of intestinal L-FABP release clearly indicates that organ manipulation during liver resection results in hepatocellular injury without causing intestinal injury.
Localization (released) of L-FABP in liver associated with injury
13) Confidence 0.39 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.83 Pain Relevance 0.28

General Comments

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