INT21465

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.69
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
neurons 1
FRTL-5 1
Epha1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 110 100.00 Very High Very High Very High
substantia gelatinosa 3 99.16 Very High Very High Very High
c fibre 4 99.08 Very High Very High Very High
Adelta 10 98.72 Very High Very High Very High
antagonist 68 98.52 Very High Very High Very High
antinociception 1 96.92 Very High Very High Very High
Locus ceruleus 1 95.20 Very High Very High Very High
spinal dorsal horn 1 93.80 High High
agonist 70 93.04 High High
Dopamine 1 86.92 High High
Disease Link Frequency Relevance Heat
Nociception 2 98.04 Very High Very High Very High
Hypersensitivity 3 79.00 Quite High
Neuropathic Pain 3 75.00 Quite High
Cv Unclassified Under Development 2 62.32 Quite High
Pain 2 51.60 Quite High
Injury 1 51.40 Quite High
INFLAMMATION 1 50.72 Quite High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of forskolin-stimulated cyclic AMP accumulation in FRTL-5 cells was employed as a functional index of A1 receptor activation.
Positive_regulation (activation) of A1 receptor in FRTL-5
1) Confidence 0.48 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2174510 Disease Relevance 0.06 Pain Relevance 0.65
Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.
Positive_regulation (enhancement) of A1 receptor associated with adenocard
2) Confidence 0.42 Published 1990 Journal Mol. Pharmacol. Section Title Doc Link 2174510 Disease Relevance 0 Pain Relevance 0.60
These data support the hypothesis that activation of the A1 receptor by the allosteric modulator, T62, produces anti-nociception via spinal noradrenergic activation.
Positive_regulation (activation) of A1 receptor in spinal associated with nociception
3) Confidence 0.33 Published 2002 Journal Pain Section Abstract Doc Link 12031785 Disease Relevance 0.62 Pain Relevance 0.88
It is concluded that adenosine presynaptically inhibits monosynaptic Adelta-fiber and C-fiber transmission by a similar extent through the activation of the A1 receptor in many but not all SG neurons; this could contribute to at least a part of antinociception by intrathecally administered adenosine analogues and probably by endogenous adenosine.
Positive_regulation (activation) of A1 receptor in neurons associated with antinociception, substantia gelatinosa, c fibre, adenocard and adelta
4) Confidence 0.29 Published 2004 Journal Neuroscience Section Abstract Doc Link 15051161 Disease Relevance 0 Pain Relevance 1.38
In contrast to the A1 receptor, which appears to modulate the myenteric reflex permanently after being activated through endogenous adenosines, the A2B receptor antagonist does not influence the latency of the ascending contraction.
Positive_regulation (activated) of A1 receptor associated with antagonist
5) Confidence 0.18 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.40
Activation of the A1 receptor further reduced the descending relaxation and the latency of the peristaltic reflex.
Positive_regulation (Activation) of A1 receptor
6) Confidence 0.18 Published 2002 Journal BMC Neurosci Section Abstract Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.50

General Comments

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