INT214692

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.20
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT3) Golgi apparatus (FUT3)
Anatomy Link Frequency
Sublingual 4
FUT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 4 77.96 Quite High
agonist 2 74.28 Quite High
anesthesia 2 35.92 Quite Low
palliative 6 33.92 Quite Low
Angina 18 5.00 Very Low Very Low Very Low
nud 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Achalasia 158 99.84 Very High Very High Very High
Esophageal Cancer 10 96.28 Very High Very High Very High
Dysphagia 25 94.36 High High
Weight Loss 14 91.56 High High
Acid Reflux 22 89.72 High High
American Trypanosomiasis 2 86.00 High High
Gastroesophageal Reflux Disease 17 81.44 Quite High
Esophageal Motility Disorder 7 73.12 Quite High
Polyps 7 68.44 Quite High
Colon Cancer 12 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a study comparing the effect of sublingual nifedipine to sublingual isosorbide dinitrate, both drugs decreased LES pressure, but the effect of nitrate was slightly better than that of nifidipine (65% vs. 49% respectively) [53].
Negative_regulation (decreased) of Gene_expression (pressure) of LES in sublingual
1) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.22 Pain Relevance 0.06
Sublingual isosorbide dinitrate is also effective in decreasing LES pressure in achalasia patients, resulting in symptom improvement in 53% to 87% of patients.
Negative_regulation (decreasing) of Gene_expression (pressure) of LES in Sublingual associated with achalasia
2) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.24 Pain Relevance 0.11
The treatment goal is to reduce the LES pressure.
Negative_regulation (reduce) of Gene_expression (pressure) of LES
3) Confidence 0.02 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990396 Disease Relevance 1.75 Pain Relevance 0

General Comments

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