INT214704

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.27
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
TK-1 2
Tk1 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 118 92.72 High High
imagery 67 92.72 High High
fibrosis 2 89.52 High High
Inflammation 8 88.68 High High
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 36 100.00 Very High Very High Very High
Cancer 406 97.24 Very High Very High Very High
Infection 13 91.60 High High
Fibrosis 2 89.52 High High
INFLAMMATION 10 88.68 High High
Skin Cancer 35 79.88 Quite High
Malignant Neoplastic Disease 4 74.48 Quite High
Metastasis 28 66.72 Quite High
Ovarian Cancer 8 50.00 Quite Low
Herpes Simplex Virus 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When taken up in cells 18F-FLT is phosphorylated by thymidine kinase-1 (TK1), which leads to intracellular trapping.
Phosphorylation (phosphorylated) of TK1
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.54 Pain Relevance 0.17
When taken up in cells 18F-FLT is phosphorylated by thymidine kinase-1 (TK1), which leads to intracellular trapping.
Phosphorylation (phosphorylated) of thymidine kinase-1
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.54 Pain Relevance 0.17
The expression of HSV1-tk can be imaged and monitored using specific radiolabeled substrates that are selectively phosphorylated by HSV1-tk and trapped within transfected cells.
Phosphorylation (phosphorylated) of HSV1-tk associated with cold sores
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651472 Disease Relevance 1.71 Pain Relevance 0.09
FLT is retained in proliferating tissues after it is phosphorylated by cytosolic thymidine kinase-1 (TK-1), one of the key cytosolic enzymes in the synthesis of DNA [15–19].
Phosphorylation (phosphorylated) of cytosolic thymidine kinase-1 in TK-1
4) Confidence 0.51 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.74 Pain Relevance 0.43
FLT is retained in proliferating tissues after it is phosphorylated by cytosolic thymidine kinase-1 (TK-1), one of the key cytosolic enzymes in the synthesis of DNA [15–19].
Phosphorylation (phosphorylated) of TK-1 in TK-1
5) Confidence 0.51 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.75 Pain Relevance 0.43

General Comments

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