INT214709

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 16
Disease Relevance 9.11
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hk2) carbohydrate metabolic process (Hk2) kinase activity (Hk2)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
body 1
Hk2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 456 97.40 Very High Very High Very High
Inflammation 28 88.04 High High
positron emission tomography 96 86.08 High High
imagery 92 57.40 Quite High
anesthesia 44 5.00 Very Low Very Low Very Low
ketamine 28 5.00 Very Low Very Low Very Low
Sciatic nerve 12 5.00 Very Low Very Low Very Low
Calcium channel 12 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 412 100.00 Very High Very High Very High
Targeted Disruption 72 99.98 Very High Very High Very High
Body Weight 36 98.56 Very High Very High Very High
Cv Unclassified Under Development 444 97.40 Very High Very High Very High
Reperfusion Injury 84 96.80 Very High Very High Very High
Necrosis 12 96.08 Very High Very High Very High
Injury 216 88.44 High High
INFLAMMATION 28 88.04 High High
Hypoxia 4 80.00 Quite High
Squamous Cell Neoplasms 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male and female heterozygote knockout HKII (HK+/-), heterozygote overexpressed HKII (HKtg), and their wild-type (WT) C57Bl/6 littermates mice were examined.
Gene_expression (overexpressed) of HKII associated with targeted disruption
1) Confidence 0.76 Published 2010 Journal Pflugers Arch Section Abstract Doc Link PMC2842566 Disease Relevance 0.60 Pain Relevance 0.13
To study alterations in the level of HK, we make use of two different HKII genotypes: the C57Bl/6 mice with a partial deletion of HKII [12; HK+/-] as well as mice overexpressing HKII (HKtg) [2].
Gene_expression (overexpressing) of HKII
2) Confidence 0.76 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.42 Pain Relevance 0.04
Finally, we examined whether HKII expression affected cell viability following the in vivo twitch-stimulated ischemia–reperfusion intervention.
Spec (whether) Gene_expression (expression) of HKII associated with ischemia
3) Confidence 0.76 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.18 Pain Relevance 0.09
However, force producing capacity, expressed per muscle weight, is not affected by overexpressing HKII.
Gene_expression (overexpressing) of HKII in muscle
4) Confidence 0.76 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.34 Pain Relevance 0
Thus, overexpressing HKII unexpectedly retards growth of skeletal muscle and body weight.
Gene_expression (overexpressing) of HKII in body associated with body weight
5) Confidence 0.66 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.29 Pain Relevance 0
However, even in this model of mild irreversible cell damage, decreasing the amount of HKII resulted in a significant (p?
Gene_expression (resulted) of HKII
6) Confidence 0.66 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.21 Pain Relevance 0.07
To study alterations in the level of HK, we make use of two different HKII genotypes: the C57Bl/6 mice with a partial deletion of HKII [12; HK+/-] as well as mice overexpressing HKII (HKtg) [2].
Gene_expression (overexpressing) of HKII
7) Confidence 0.66 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.49 Pain Relevance 0.04
However, even in this model of mild irreversible cell damage, decreasing the amount of HKII resulted in a significant (p?
Gene_expression (amount) of HKII
8) Confidence 0.66 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.21 Pain Relevance 0.07
To study alterations in the level of HK, we make use of two different HKII genotypes: the C57Bl/6 mice with a partial deletion of HKII [12; HK+/-] as well as mice overexpressing HKII (HKtg) [2].
Spec (partial) Gene_expression (deletion) of HKII
9) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.48 Pain Relevance 0.04
Overexpressing HKII resulted in a robust increase in HK activity (360% for male and 480% for female).
Gene_expression (Overexpressing) of HKII
10) Confidence 0.57 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.43 Pain Relevance 0
Male and female heterozygote knockout HKII (HK+/-), heterozygote overexpressed HKII (HKtg), and their wild-type (WT) C57Bl/6 littermates mice were examined.
Gene_expression (overexpressed) of HKII associated with targeted disruption
11) Confidence 0.51 Published 2010 Journal Pflugers Arch Section Abstract Doc Link PMC2842566 Disease Relevance 0.60 Pain Relevance 0.13
Thus, overexpressing HKII unexpectedly retards growth of skeletal muscle and body weight.
Gene_expression (overexpressing) of HKII in skeletal muscle associated with body weight
12) Confidence 0.22 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.29 Pain Relevance 0
Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).
Gene_expression (expression) of HK II associated with cancer
13) Confidence 0.22 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.56 Pain Relevance 0.03
Compared to the control group, high levels—though not statistically significant—of glucose transporter-1, HK II, and Ki67 expression were found at the end of treatment in both FDG and FLT groups.
Gene_expression (expression) of HK II
14) Confidence 0.22 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.60 Pain Relevance 0.04
Notable findings for irradiated tumors as compared to control tumors were high levels of Glut-1 expression (13 of 15 tumors), HK II (9 of 16 tumors), and Ki-67 expression (12 of 13 tumors).
Gene_expression (expression) of HK II associated with cancer
15) Confidence 0.22 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.57 Pain Relevance 0.03
All tumors demonstrated expression of glucose transporter-1, thymidine kinase-1, and hexokinase II.
Gene_expression (expression) of hexokinase II associated with cancer
16) Confidence 0.19 Published 2007 Journal Mol Imaging Biol Section Abstract Doc Link PMC2040178 Disease Relevance 0.84 Pain Relevance 0.16

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