INT2148

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 105
Total Number 106
Disease Relevance 11.42
Pain Relevance 57.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 16
neurons 7
nucleus 4
spinal cord 4
myometrium 3
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 142 100.00 Very High Very High Very High
Opioid 104 100.00 Very High Very High Very High
Morphine 99 100.00 Very High Very High Very High
Enkephalin 50 100.00 Very High Very High Very High
Dismenorea 17 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
depression 5 100.00 Very High Very High Very High
neuropeptide release 1 100.00 Very High Very High Very High
fluoxetine 96 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 13 100.00 Very High Very High Very High
Depression 5 100.00 Very High Very High Very High
Aggression 11 99.90 Very High Very High Very High
Pressure Volume 2 Under Development 6 99.88 Very High Very High Very High
Volume Depletion And Dehydration 8 99.76 Very High Very High Very High
Urological Neuroanatomy 45 99.68 Very High Very High Very High
Spasticity 1 99.64 Very High Very High Very High
Pain 23 99.58 Very High Very High Very High
Stress 27 99.16 Very High Very High Very High
Amnesia 1 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate central endogenous opioid inhibition of OXT neurone activity in late pregnancy which may restrain premature OXT release.
Negative_regulation (inhibition) of OXT associated with endogenous opioid
1) Confidence 0.59 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542430 Disease Relevance 0 Pain Relevance 0.61
We conclude that the decreased oxytocin concentrations prepartum, the prolongation of parturition and the decrease in opioid tone in ovariectomized steroid-treated rats may be partly due to a lack of relaxin produced by the ovary.
Negative_regulation (decreased) of oxytocin in ovary associated with opioid
2) Confidence 0.59 Published 1993 Journal J. Endocrinol. Section Abstract Doc Link 7852884 Disease Relevance 0 Pain Relevance 0.48
Subcutaneous injections of morphine decrease the plasma oxytocin level significantly in both normohydrated rats and rats dehydrated for 24 hrs.
Negative_regulation (decrease) of plasma oxytocin in plasma associated with morphine
3) Confidence 0.59 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2848232 Disease Relevance 0.08 Pain Relevance 0.55
This delay is accompanied by reduced plasma oxytocin levels and is overcome by treatment either with the opioid antagonist naloxone, or by infusion of oxytocin.
Negative_regulation (reduced) of oxytocin in plasma associated with antagonist, narcan and opioid
4) Confidence 0.59 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2842005 Disease Relevance 0 Pain Relevance 0.67
Galanin 0.1 and 1 microgram given intracerebroventricularly or intraperitoneally significantly decreased the oxytocin level in plasma 60 min after injection.
Negative_regulation (decreased) of oxytocin in plasma
5) Confidence 0.58 Published 1993 Journal Brain Res. Section Abstract Doc Link 7684311 Disease Relevance 0.40 Pain Relevance 0.49
Antinociceptive effect of oxytocin was inhibited by subsequent perfusion of cerebral ventricles with oxytocin antagonist, [deamino-Cys1-D-Tyr(OEt)2-Thr4-Orn8]-oxytocin, atosiban.
Negative_regulation (inhibited) of oxytocin in ventricles associated with antagonist and antinociceptive
6) Confidence 0.58 Published 2005 Journal Brain Res. Section Abstract Doc Link 15713278 Disease Relevance 0.08 Pain Relevance 0.88
Initially, a decrease in plasma oxytocin levels was seen 30 min after injection.
Negative_regulation (decrease) of oxytocin in plasma
7) Confidence 0.58 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.17
The initial decrease in plasma oxytocin reversed, and 4 h after injection of bremazocine a 20-fold increase in the oxytocin level was seen.
Negative_regulation (decrease) of oxytocin in plasma
8) Confidence 0.58 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.19
The data suggest (1) that in addition to opioid receptors, 'presynaptic' alpha 2-receptors regulate release from neurohypophysial noradrenaline terminals; (2) noradrenaline released from neurohypophysial terminals acts on beta- and alpha 1-receptors to facilitate both oxytocin and arginine vasopressin release: this action only becoming evident at elevated levels of endogenous noradrenaline release attained following removal of presynaptic opioid or alpha 2-regulation, and (3) opioid peptides within the neurohypophysis act to inhibit oxytocin and, to a lesser extent, arginine vasopressin secretion, partly through inhibiting release of facilitatory noradrenaline.
Negative_regulation (inhibit) of oxytocin in neurohypophysis associated with noradrenaline, opioid receptor and opioid
9) Confidence 0.58 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 2845292 Disease Relevance 0 Pain Relevance 1.25
The effects of oxytocin were also totally inhibited by co-perfusion with 5x10(-8) mol/L tetrodotoxin (P<0.02) or 10(-6) mol/L atropine (P<0.03) but not by 10(-6) mol/L hexamethonium, which implies that these effects are neurally mediated, primarily by intrinsic parasympathetic postganglionic neurons.
Negative_regulation (inhibited) of oxytocin in neurons associated with tetrodotoxin
10) Confidence 0.55 Published 2001 Journal Hypertension Section Abstract Doc Link 11509492 Disease Relevance 0.07 Pain Relevance 0.15
The administration of ANF III in conscious euhydrated rats resulted in a significant reduction of both AVP and OXT contents in the hippocampus.
Negative_regulation (reduction) of OXT in hippocampus associated with hippocampus
11) Confidence 0.52 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.16 Pain Relevance 0.19
Pethidine (also known as meperidine and as Demerol) injected subcutaneously at 10 mg/kg into parturient rats on the birth of the second pup resulted in a marked slowing of the progress of parturition, associated with reduced plasma oxytocin concentrations.
Negative_regulation (reduced) of oxytocin in plasma associated with algil
12) Confidence 0.51 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1877695 Disease Relevance 0 Pain Relevance 0.71
Acute down-regulation of oxytocin and vasopressin mRNA levels following metrazole-induced seizure in the rat.
Negative_regulation (down-regulation) of oxytocin associated with convulsion and enkephalin
13) Confidence 0.50 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8247343 Disease Relevance 0.10 Pain Relevance 0.17
In conclusion, TT-235 may inhibit the uterine response to oxytocin by decreasing oxytocin receptor numbers and oxytocin binding affinity, which might explain the prolonged oxytocin antagonist activity of TT-235.
Negative_regulation (numbers) of oxytocin in uterine associated with antagonist
14) Confidence 0.48 Published 2004 Journal In Vivo Section Abstract Doc Link 15646817 Disease Relevance 0 Pain Relevance 0.12
Cocaine treatment also resulted in a significant down-regulation of oxytocin receptors in the medial preoptic area and both cocaine and fluoxetine treated dams had the highest affinity for oxytocin receptors in this brain region.
Negative_regulation (down-regulation) of oxytocin in medial associated with urological neuroanatomy, fluoxetine and cocaine
15) Confidence 0.45 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15380831 Disease Relevance 0.37 Pain Relevance 1.09
Cocaine administered chronically throughout gestation has been correlated with deficits in maternal behavior, increased maternal aggressive behavior and decreased oxytocin levels in rats.
Negative_regulation (decreased) of oxytocin associated with aggression and cocaine
16) Confidence 0.45 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15380831 Disease Relevance 0.30 Pain Relevance 0.36
Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed.
Negative_regulation (suppression) of OXT in plasma associated with agonist, opiate and intracerebroventricular
17) Confidence 0.44 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8923507 Disease Relevance 0 Pain Relevance 0.31
Pain stimulation induced oxytocin concentration decrease in the hypothalamic supraoptic nucleus, and increase in the locus coeruleus, raphe magnus nucleus, caudate nucleus and spinal cord, but no change in the hypothalamic paraventricular nucleus and plasma.
Negative_regulation (decrease) of oxytocin in caudate nucleus associated with raphe magnus, pain, locus ceruleus and spinal cord
18) Confidence 0.43 Published 2007 Journal Peptides Section Abstract Doc Link 17420069 Disease Relevance 0.28 Pain Relevance 0.72
Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.
Negative_regulation (depletion) of oxytocin in posterior pituitary associated with narcan and enkephalin
19) Confidence 0.43 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7700499 Disease Relevance 0.05 Pain Relevance 0.92
We now report that acute stimulation of the rat neural lobe in vivo results in depletion of the neural lobe content of OXT, AVP, dynorphin A1-17, dynorphin A1-8 and metenkephalin (Met-Enk).
Negative_regulation (depletion) of OXT in neural lobe associated with dynorphin
20) Confidence 0.43 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7700499 Disease Relevance 0.06 Pain Relevance 0.89

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