INT21482

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Context Info
Confidence 0.12
First Reported 1983
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.35
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Morph1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 18 100.00 Very High Very High Very High
Morphine 11 100.00 Very High Very High Very High
Physical dependence 3 100.00 Very High Very High Very High
opiate 9 99.92 Very High Very High Very High
tolerance 5 99.84 Very High Very High Very High
Antinociceptive 2 99.30 Very High Very High Very High
narcan 8 98.60 Very High Very High Very High
Dopamine 1 96.60 Very High Very High Very High
agonist 4 92.72 High High
analgesia 1 90.64 High High
Disease Link Frequency Relevance Heat
Drug Dependence 3 100.00 Very High Very High Very High
Sprains And Strains 3 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antinociceptive tolerance, cross-tolerance and an expression of physical dependence to morphine (MRP) and (+/-)-ethylketazocine (EKC) were quantitatively compared using two inbred strains of mice.
Gene_expression (expression) of morphine associated with physical dependence, tolerance, sprains and strains, antinociceptive and morphine
1) Confidence 0.12 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6092614 Disease Relevance 0.35 Pain Relevance 1.05
Thus the sensitization to the feeding effects of MORPH and U50 produced by chronic AMPH administration appears to involve different systems; the mesolimbic dopamine system appears to mediate sensitization to the effects of the predominately mu-receptor agonist, MORPH, but not of the kappa-receptor agonist, U50.
Gene_expression (produced) of MORPH associated with dopamine and agonist
2) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2174718 Disease Relevance 0 Pain Relevance 0.68
Studies revealed that tripelennamine (Tp) alone produced antinociception (ANTI) in mice and also caused potentiation when combined with morphine (M) or nalbuphene (NB).
Gene_expression (produced) of antinociception associated with antinociception and morphine
3) Confidence 0.08 Published 1983 Journal Life Sci. Section Abstract Doc Link 6835002 Disease Relevance 0 Pain Relevance 1.16
The effect of tripelennamine alone and in combination with opiates to produce antinociception in mice.
Gene_expression (produce) of antinociception associated with antinociception, narcan and opiate
4) Confidence 0.08 Published 1983 Journal Life Sci. Section Title Doc Link 6835002 Disease Relevance 0 Pain Relevance 1.30

General Comments

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